Last updated: January 30, 2023
Sponsor: Defence Medical Rehabilitation Centre, UK
Overall Status: Active - Recruiting
Phase
N/A
Condition
Polymyositis (Inflammatory Muscle Disease)
Sarcopenia
Treatment
N/AClinical Study ID
NCT05719922
DefenceMedRC
Ages 18-55 All Genders
Study Summary
Eligibility Criteria
Inclusion
Inclusion Criteria:
- mechanical knee pain for at least three months
- present with clinical signs and symptoms of knee pain arising from the tibiofemoral orpatellofemoral joint diagnosed by sport and exercise medicine physician and/orphysiotherapist
- have reduced occupational employability medical grade secondary to their knee pain
- report progression of resistance training load within the patient's rehabilitationprogramme is limited by knee pain
- aged between 18 and 55 years
- available to attend for the entire duration of the RRU course and a review appointment 3-months following course.
Exclusion
Exclusion Criteria: diagnosed tibial, femoral or patella fracture and/or dislocation;
- present with instability in the knee resulting from ligament deficiency
- present with clinical signs and symptoms of patellar tendinopathy
- have planned surgery over the study period
- restricted knee range of movement; clinical signs and symptoms of non-musculoskeletalor serious pathological condition (i.e. Inflammatory arthropathy, infection or tumour)or referred pain from non-local pain source
- present with any physical impairment or co-morbidities (including cardio-vasculardisease) precluding the safe participation in the rehabilitation programme and/orassessment procedures
- Cortico-steroid or analgesic injection intervention within the previous 7-days orprevious knee surgery within the last 12 months to the affected limb Medical Exclusion Criteria:
- History of cardiovascular disease including hypertension, peripheral vascular disease,thrombosis/embolism, ischaemic heart disease, myocardial infarction.
- History of the following musculoskeletal disorders: rheumatoid arthritis, avascularnecrosis or osteonecrosis, severe osteoarthritis.
- History of the following neurological disorders: Peripheral neuropathy, Alzheimer'sdisease, amyotrophic lateral sclerosis, Parkinson's disease, severe traumatic braininjury.
- Varicose veins in the lower limb
- Acute viral or bacterial upper or lower respiratory infection at screening
- Known or suspected lower limb chronic exertional compartment syndrome (CECS)
- Postsurgical swelling
- Surgical insertion of metal components at the position of cuff inflation
- History of any of the following conditions or disorders not previously listed:diabetes, active cancer
- History of elevated risk of unexplained fainting or dizzy spells during physicalactivity/exercise that causes loss of balance
- History of haemorrhagic stroke or exercise induced rhabdomyolysis
Study Design
Total Participants: 150
Study Start date:
December 01, 2022
Estimated Completion Date:
August 31, 2024
Connect with a study center
RRU Aldershot
Aldershot,
United KingdomActive - Recruiting
RRU Colchester
Colchester,
United KingdomActive - Recruiting
RRU Cranwell
Cranwell,
United KingdomActive - Recruiting
RRU Edinburgh
Edinburgh,
United KingdomActive - Recruiting
RRU St Athan
St Athan,
United KingdomActive - Recruiting
RRU Bulford
Tidworth,
United KingdomActive - Recruiting
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