Clonal Architecture of ASXL1-mutated Myelofibrosis

Last updated: February 6, 2025
Sponsor: University Hospital, Angers
Overall Status: Active - Recruiting

Phase

N/A

Condition

Myelofibrosis

Post-polycythemia Vera Myelofibrosis

Treatment

Clonal architecture determination

Clinical Study ID

NCT05710211
2022-A02497-36
  • Ages > 18
  • All Genders

Study Summary

Prospective study to decipher the clonal architecture of ASXL1-mutated primary and secondary myelofibrosis and its impact on prognosis

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Adults (age ≥18 years),

  • Affiliated to the national social security system,

  • ASXL1 mutated primary or secondary myelofibrosis,

  • Signed the consent to participate in the study,

  • Included, or consenting to be included, in the national clinical-biological databaseof France Intergroupe Syndrome Myéloprolifératifs (FIM).

Exclusion

Exclusion Criteria:

  • Patient with another active hematological disease or cancer at the time ofdiagnosis,

  • Person subject to legal protection scheme or incapable of giving consent.

Study Design

Total Participants: 50
Treatment Group(s): 1
Primary Treatment: Clonal architecture determination
Phase:
Study Start date:
April 24, 2023
Estimated Completion Date:
April 30, 2031

Study Description

The clonal architecture of myelofibrosis patients is still little described. Inconsistent results in terms of the prognostic value of some mutations are observed in the literature, in particular concerning ASXL1 mutations. We assume that a better understanding of the clonal architecture of ASXL1-mutated myelofibrosis could help refining the prognostic impact of ASXL1 mutations.

This study aims to evaluate a multicenter cohort of 50 patients. Blood of patients will be collected within 18 months of diagnosis. After 4 years of follow-up of the patient as part of his usual care, data on survival and leukemic transformation will be collected.

Connect with a study center

  • CHU Angers

    Angers,
    France

    Active - Recruiting

  • CHRU Brest

    Brest,
    France

    Site Not Available

  • CH Cholet

    Cholet,
    France

    Site Not Available

  • CHU Henri MONDOR

    Creteil, 94010
    France

    Active - Recruiting

  • Institut Paoli Calmettes

    Marseille, 13009
    France

    Active - Recruiting

  • CHU Nantes

    Nantes,
    France

    Site Not Available

  • AP-HP Hôpital Saint Louis

    Paris, 75010
    France

    Site Not Available

  • Hôpital Bicêtre

    Paris,
    France

    Active - Recruiting

  • CHU de Bordeaux

    Pessac, 33604
    France

    Active - Recruiting

  • CHU Lyon

    Pierre Bénite, 69495
    France

    Active - Recruiting

  • CH de Cornouaille

    Quimper,
    France

    Site Not Available

  • CHRU Tours - Hôpital Bretonneau

    Tours,
    France

    Active - Recruiting

  • CH de Vannes

    Vannes,
    France

    Site Not Available

Not the study for you?

Let us help you find the best match. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.