A Study of AMDX-2011P in Participants With CAA

Inclusion Criteria:

1. Diagnosis of hereditary CAA or probable and definite symptomatic or asymptomaticsporadic CAA diagnosed through genetic testing or according to the modified Bostonneuroradiological criteria, who had undergone at least one brain magnetic resonanceimaging (MRI)prior to entry into study.

2. Abnormality consistent with CAA on historical MRI.

3. In general good health

Exclusion Criteria:

1. Presence of any underlying physical or psychological medical condition that, in theopinion of the investigator, would make it unlikely that the participant willcomplete the study per protocol.

2. Clinically significant laboratory abnormalities assessed by the investigator.

3. Active malignancy and/or history of malignancy in the past 5 years, with theexception of completely excised non-melanoma skin cancer or low-grade cervicalintraepithelial neoplasia.

4. Prolonged QTcF (>450 ms for males and >470 ms for females),cardiac arrhythmia, orany clinically significant abnormality in the resting ECG, as judged by theinvestigator.