Clinical Trial to Determine the Effectiveness and Safety of Topical Insulin in Dry Eye

Inclusion Criteria:

• Patients older than 18 years

• Dry eye disease diagnosis

• Treatment with artificial tears or hyaluronic acid gels for at least 3 months

• Signed informed consent by the patient

• Staining equal to or greater than Oxford II

Exclusion Criteria:

• Under 18 years old

• Corneal staining under Oxford II

• Treatment for dry eye disease other than artificial tears or hyaluronic acid gels

• Severe dry eye disease that requires immediate treatment

• Eye surgery in the last 6 months

• Other concomitant corneal pathology, eyelid malpositions, nasolacrimal drainageabnormalities, blinking alterations

• Contact lenses

• Other treatment besides artificial tears or hyaluronic acid gels

• Visual acuity less than 0.1

• Allergy or intolerance to any of the components included in the study

• Modifications in systemic immunosuppressive treatment

• Pregnancy or lactation

• Women of childbearing age who do not use a highly effective contraceptive method

• History of alcohol or drug abuse

• Participation in another clinical trial in the last 30 days

• Systemic pathology (cardiopulmonary pathology, connective tissue disorders,neurological or psychiatric pathology) or baseline situation of the patient thatdoes not allow the examination (such as mental or psychomotor retardation)