Assessment of the Effect of Non-surgical Periodontal Treatment on Endothelial Function- a Prospective Study

Last updated: January 21, 2023
Sponsor: University of Sharjah
Overall Status: Active - Recruiting

Phase

N/A

Condition

Atherosclerosis

Treatment

N/A

Clinical Study ID

NCT05691426
REC-22-02-28-04-S
  • Ages > 18
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

An association between periodontitis and endothelial dysfunction has been reported, suggesting that periodontitis presents an inflammatory burden to the cardiovascular system, that might lead to AVD. The study aims aim to assess whether non-surgical periodontal therapy enhances endothelial function in periodontitis patients using a non-invasive diagnostic device to assess endothelial function through PWA and the assessment of levels of salivary Endothelin-1, in a population of people in the UAE.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Group 1: periodontally healthy subjects.
  • Group 2: patients with periodontitis stage III or IV and grades A,B or C.

Exclusion

Exclusion Criteria:

  • Medical conditions: Diabetes,pregnancy,obesity,renal disease,patients withcardiovascular diseases including hypertension,recent myocardial infarction orunstable angina (within 3 months),congestive heart failure,valvular heart disease
  • Heavy smokers(>10 cigarettes per day),
  • Regular administration of drugs resulting in gingival hyperplasia,root planning in thepast 6 months
  • Regular administration of drugs resulting in gingival hyperplasia (such ascyclosporine and phenytoin)
  • Recent antibiotic use (in the past 3 months)
  • Non-surgical periodontal therapy in the past 6 monthsp

Study Design

Total Participants: 40
Study Start date:
October 01, 2022
Estimated Completion Date:
June 30, 2024

Connect with a study center

  • University Dental Hospital Sharjah

    Sharjah,
    United Arab Emirates

    Active - Recruiting

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