Opium Tincture Against Chronic Diarrhea - Patients

Inclusion Criteria:

• • Signed informed consent before any study specific procedures
• Able to read and understand Danish
• Male or female with an age of 20 years or more
• The researcher believes that the participant understands what the study entails,are capable of following instructions, can attend when needed, and are expectedto complete the study.
• The investigator will ensure that fertile female participants have a negativepregnancy test before each treatment visit and use contraception during theentity of the study.
• Specific underlying pathophysiology has been identified, but targeted treatment (e.g. antibiotics or bile acid sequestrants) and treatment with loperamide hasfailed. OR
• No specific underlying pathophysiology has been identified and treatment withloperamide has failed.
• At least 6 months post-surgery in the gastrointestinal tract
• No sign of cancer at standard clinical follow-up
• Chronic diarrhea defined as at least 3 daily bowel movements for the last week

Exclusion Criteria:

• • Known allergy towards pharmaceutical compounds similar to Dropizol.
• Participation in other studies within 14 days of first visit (1 year if opioidsinvolved).
• Expected need of medical/surgical treatment during the study
• History of psychiatric illness (e.g. mental retardation, schizophrenia, majordepression)
• History of substance abuse (e.g. alcohol, THC, benzodiazepine, central stimulantsand/or opioids)
• Family history of substance abuse
• Known major stenosis of the intestines
• Known severe decreased renal function (defined as eGFR below 30)
• Known severe decreased hepatic function (defined as Child-Pugh class B or higher)
• Treatment with MAO- inhibitors during the entity of the study
• Severe COPD or acute severe asthma (defined as FEV1 below 50 % or acute ongoingexacerbation)
• Known cor pulmonale
• Female participants that are lactating
• Medicine known to affect gastrointestinal motility must not be initiated duringthe entity of the study
• Treatment with opium tincture during the last month