The Molecular Pathogenesis Study of Cataract

Last updated: January 3, 2023
Sponsor: Eye & ENT Hospital of Fudan University
Overall Status: Active - Recruiting

Phase

N/A

Condition

Vision Loss

Eye Disorders/infections

Eye Disease

Treatment

N/A

Clinical Study ID

NCT05682001
CMP
  • Ages 18-90
  • All Genders

Study Summary

To study the molecular pathogenesis of cataract and explore possible treatments，anterior lens capsules were collected from cataract patients

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • diabetic cataract
  • underwent cataract surgery

Exclusion

Exclusion Criteria:

  • Combined with other eye diseases
  • underwent other eye surgery

Study Design

Total Participants: 150
Study Start date:
January 01, 2022
Estimated Completion Date:
December 30, 2025

Study Description

Anterior lens capsules were collected from the patients with DC and ARC, and transparent crystals of cadaveric eyes. M6A epitranscriptomic microarray was performed to investigate the altered m6A modifications and determine the differentially expressed mRNAs. The potential role of dysregulated m6A modification levels was predicted through Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses. Real-time polymerase chain reaction was performed to identify the dysregulated expression of RNA methyltransferases, demethylases, and readers.

Connect with a study center

  • Eye & ENT Hospital of Fudan University

    Shanghai, Shanghai 200031
    China

    Active - Recruiting

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