Role of IL-5R Signaling in Non-eosinophil Upper Airway Cells in CRSwNP

Last updated: January 5, 2023
Sponsor: Brigham and Women's Hospital
Overall Status: Active - Recruiting

Phase

N/A

Condition

Polyps

Nasal Obstruction

Rhinitis, Allergic, Perennial

Treatment

N/A

Clinical Study ID

NCT05672030
2003P002088
  • Ages > 18
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

The overarching hypothesis of this proposal is that IL-5 acts on multiple sinus tissue cell types, including plasma cells and epithelial cells, to promote immune dysregulation, and that inhibition of IL-5 affects several relevant effector pathways that lead to clinical benefit.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • AERD, CRSwNP, healthy controls

Exclusion

Exclusion Criteria:

  • Not on any systemic steroids or respiratory biologics at time of surgery

Study Design

Total Participants: 30
Study Start date:
October 01, 2022
Estimated Completion Date:
December 01, 2023

Study Description

Further characterization of the role of IL-5Rα expression and function on human plasma cells will determine whether inhibiting IL-5 signaling on these cells offers therapeutic promise in other diseases related to plasma cell proliferation. Further characterization of human upper airway epithelial cell IL-5Rα expression and function will determine whether or not inhibiting IL-5 signaling on these cells offers therapeutic promise in other diseases related to epithelial dysfunction. IL-5Rα expression has been identified on several relevant sinus tissue effector cells, including on nasal polyp plasma cells and epithelial cells, and the aim of this study is to further the field by determining the consequences of IL-5 signaling on those cells.

Connect with a study center

  • Brigham and Women's Hospital

    Boston, Massachusetts 02115
    United States

    Active - Recruiting

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