Study of TTI-101 in Participants With Idiopathic Pulmonary Fibrosis

Inclusion Criteria:

1. Diagnosed with IPF based on either the 2018 American Thoracic Society (ATS)/European Respiratory Society (ERS)/ Japanese Respiratory Society (JRS)/ LatinAmerican Thoracic Association (ALAT) International Diagnostic Guidelines or on the 2022 updated guidelines within 7 years prior to the date of informed consent.

2. Chest high-resolution computed tomography scan (HRCT) performed within 12 monthsprior to providing informed consent meeting requirements for IPF diagnosis based on 2018 or 2022 ATS/ERS/JRS/ALAT guidelines and confirmed by central review.

3. Greater than 40% of predicted forced vital capacity (FVC) and a ratio of forcedexpiratory volume in 1 second (FEV1)/FVC ≥0.7 measured pre-bronchodilator duringscreening confirmed by central review.

4. A predicted diffusing capacity of the lungs for carbon monoxide (DLCO) (hemoglobin [Hb] corrected) ≥25% during screening confirmed by central review.

5. Oxygen saturation (SpO2) ≥88% with up to 4L O2/min by pulse oximetry at rest.

6. If currently receiving nintedanib, dose must have been stable for ≥3 months prior torandomization. If participant has previously discontinued nintedanib, there is a 6-week washout period required before screening can begin.

7. Has a life expectancy of at least 12 months.

Exclusion Criteria:

1. Unresolved respiratory tract infection within 4 weeks (including coronavirus disease 2019 [COVID-19] infections) or an acute exacerbation of IPF within 3 months prior toscreening.

2. Planned surgery during the study.

3. The investigator judges that there has been sustained improvement in the severity ofIPF during the 12 months prior to screening, based on changes in FVC, DLCO, and/orHRCT scans of the chest.

4. History of other types of respiratory diseases including diseases or disorders ofthe airways, lung parenchyma, pleural space, mediastinum, diaphragm, or chest wallthat, in the opinion of the investigator, would impact the primary protocol endpointor ability to do pulmonary function tests (PFTs), or otherwise precludeparticipation in the study.

5. Likely to have lung transplantation during the study. Note: Participant may be on alung transplant list if the investigator anticipates the participant will be able tocomplete the study prior to transplant.

6. Clinically relevant and uncontrolled cardiac, hepatic, gastrointestinal, renal,endocrine, metabolic, neurologic, or psychiatric disorders that may interfere withthe participant's ability to complete this study according to the investigator'sjudgment, or logistical challenges that, in the opinion of the investigator,preclude adequate participation in the study.

7. History or difficulty of swallowing, malabsorption, or other chronicgastrointestinal disease or conditions that may hamper compliance and/or absorptionof the study drug.

8. Receiving steroids (excluding topical steroids) in excess of a mean of 10 mg/day ofprednisolone or its equivalent within 2 weeks prior to randomization.

9. Received pirfenidone within 3 months prior to randomization.

10. Smoking or vaping of any kind within 3 months of screening.