An Extension Study to Assess Long-Term Safety of Eplontersen in Adults With Transthyretin-Mediated Amyloid Cardiomyopathy (ATTR-CM)

Inclusion Criteria:

1. Satisfactory completion of Treatment Period and the End of Treatment Visit of theIndex Study (ION-682884-CS2) OR diagnosis of ATTR-CM and satisfactory participationon ISIS 420915- CS101 study as judged by the Investigator and Sponsor.

2. Investigator is willing to treat the participant with open-label eplontersen.

3. Willingness to adhere to vitamin A supplementation per protocol.

Exclusion Criteria:

1. Permanently discontinued study drug administration while participating in the IndexStudy (ION 682884-CS2) or IST (ISIS 420915-CS101 Study).

2. Have any new condition or worsening of an existing condition that in the opinion ofthe Investigator or Sponsor would make the participant unsuitable for enrolment, orwhich could interfere with the participant participating in or completing the study,including the need for treatment with medications disallowed in the Index Study.