MAD Trial: Myopia Atropine Dose

Inclusion Criteria:

• Children aged 6 to ≤ 11 years with bilateral myopia
• Onset of myopia ≥ 4 years of age
• History of progression ≥ -0.5D/yr.
• SER of at least -1.50D and no greater than -6.00D in each eye measured usingcycloplegic auto refraction
• Intraocular pressure < 21 mm Hg in each eye
• Distance vision correctable to at least 0.1 Log MAR (logarithm of the minimum angle ofresolution) in each eye

Exclusion Criteria:

• Allergy to atropine or other excipients of the eye drops
• History of amblyopia or strabismus
• History of retinal dystrophy or systemic disorder
• Abnormal ocular biometry aside from axial length
• History of glaucoma
• Chronic use of topical or systemic antimuscarinic/anticholinergic medications in the 21 days prior to screening, and/or anticipated need for chronic use over the durationof the study (i.e., more than 7 consecutive days in 1 month or more than a total of 30days in 1 year).
• Chronic use (more than 3 days a week) of topical ophthalmological medication (prescribed or over the counter) other than the assigned study medication. The use ofartificial tears is allowed but not in the 1 hour before or after the administrationof the study medication.
• The anticipated need to use chronic ophthalmic or systemic oral corticosteroids duringthe study. (i.e., < 2 weeks)
• Prior myopia treatments.
• Employees of the study center and their family members.