MAD Trial: Myopia Atropine Dose

Inclusion Criteria:

• Children aged 6 to ≤ 11 years with bilateral myopia

• Onset of myopia ≥ 4 years of age

• History of progression

• SER of at least -1.00D and no greater than -6.00D in each eye measured usingcycloplegic auto refraction

• Intraocular pressure < 21 mm Hg in each eye

• Distance vision correctable to at least 0.1 Log MAR (logarithm of the minimum angleof resolution) in each eye

Exclusion Criteria:

• Allergy to atropine or other excipients of the eye drops

• History of amblyopia or strabismus

• History of retinal dystrophy or systemic disorder

• Abnormal ocular biometry aside from axial length

• History of glaucoma

• Chronic use of topical or systemic antimuscarinic/anticholinergic medications in the 21 days prior to screening, and/or anticipated need for chronic use over theduration of the study (i.e., more than 7 consecutive days in 1 month or more than atotal of 30 days in 1 year).

• Chronic use (more than 3 days a week) of topical ophthalmological medication (prescribed or over the counter) other than the assigned study medication. The useof artificial tears is allowed but not in the 1 hour before or after theadministration of the study medication.

• The anticipated need to use chronic ophthalmic or systemic oral corticosteroidsduring the study. (i.e., < 2 weeks)

• Prior myopia treatments.

• Employees of the study center and their family members.