Effects of Radiofrequency Ablation of Posterior Nasal Nerves on Inflammatory Cytokines, Peak Nasal Inspiratory Flow, and Nasal Blood Flow in Patients With Chronic Rhinitis

Last updated: March 18, 2025
Sponsor: The University of Texas Health Science Center, Houston
Overall Status: Completed

Phase

N/A

Condition

Common Cold

Allergy

Nasal Obstruction

Treatment

Radiofrequency ablation (RFA)

Clinical Study ID

NCT05648565
HSC-MS-22-0899
  • Ages 18-80
  • All Genders

Study Summary

The purpose of this study is to assess the effectiveness of radiofrequency ablation (RFA) of the posterior nasal nerve (PNN) in chronic rhinitis (CR) patients by comparing patient reflective total nasal symptom score (rTNSS) and nasal obstruction symptom evaluation (NOSE) , peak nasal inspiratory flow (PNIF) , and levels of Type 2 cytokines pre- and post-procedure.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • chronic rhinitis symptoms for at least 6 months (rhinorrhea, congestion, post-nasaldrip)

  • poor response to medical management that was attempted for at least 4 weeks

  • a rTNSS score ≥6, as well as ≥2 for rhinorrhea, and ≥1 for congestion.

Exclusion

Exclusion Criteria:

  • active sinusitis

  • rhinitis medicamentosa

  • recurrent and ongoing epistaxis

  • immunodeficiency as defined by an illness or a history of sinus surgery.

Study Design

Total Participants: 17
Treatment Group(s): 1
Primary Treatment: Radiofrequency ablation (RFA)
Phase:
Study Start date:
January 10, 2023
Estimated Completion Date:
February 20, 2024

Connect with a study center

  • The University of Texas Health Science Center at Houston

    Houston, Texas 77030
    United States

    Site Not Available

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