Features of Regional Perfusion of Lung Consolidation

Last updated: December 8, 2022
Sponsor: Peking Union Medical College Hospital
Overall Status: Active - Recruiting

Phase

N/A

Condition

Lung Injury

Acute Respiratory Distress Syndrome (Ards)

Treatment

N/A

Clinical Study ID

NCT05647967
I-22PJ140
  • Ages 18-90
  • All Genders

Study Summary

The aim of this study is to evaluate the potential usefulness of lung ultrasound to assess the size and perfusion of consolidation and explore their relationships with clinical outcome.

Eligibility Criteria

Inclusion

Inclusion criteria:

  1. Admission to ICU( 18yr<age<90yr);
  2. Patients presented with acute respiratory failure;
  3. Pulmonary consolidation by chest imaging (lung ultrasound, X ray or CT scan).

Exclusion

Exclusion criteria:

  1. Hemodynamic instability (i.e., severe hypotension with systolic arterialpressure<60mmHg despite fluid expansion and vasoactive support; systolic arterialpressure>180mmHg; uncontrolled cardiac arrhythmias);
  2. Severe thoracic trauma;
  3. Coronavirus disease 2019;
  4. Pulmonary artery hypertension and pregnancy.

Study Design

Total Participants: 200
Study Start date:
January 01, 2022
Estimated Completion Date:
January 31, 2024

Study Description

Lung consolidation is one of the most causes of hypoxia in intensive care unit(ICU) settings. A quantitative measurement of consolidation would be extremely benefit for the clinical management in hypoxemia, both as an index of severity and to predict outcomes.In order to quantify the lung consolidation and its effect on clinical outcomes, a simple and quantitative scoring system of the size and perfusion of lung consolidation was proposed by lung ultrasound. Subjects with respiratory failure and lung consolidation proved by chest imaging underwent lung ultrasound examination. The size of consolidation and the richness of blood flow was computed upon lung ultrasound. The sensitivity, specificity and accuracy of the scoring system were calculated and compared to evaluate the diagnostic efficacy.

Connect with a study center

  • Peking union medical college hospital

    Beijing, Beijing 100010
    China

    Active - Recruiting

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