Biomarkers of Sleep-wake Cycle in Prodromal Alzheimer's Disease: Role in Cognitive Decline?

Inclusion Criteria:

• Diagnosis of mild Alzheimer's disease with a Mini Mental State (MMS) between 21-30

• The presence of a family carer to complete neuropsychological scales, questionnairesand sleep diaries

• Having a neurological assessment and/or follow-up requiring blood and cerebrospinalfluid (CSF) sampling with biomarkers for diagnostic purposes

• Patient who had a lumbar puncture less than one year ago or patient with a scheduledlumbar puncture as part of care

• Signed informed consent

• Able to carry out all visits and follow study procedures

• Affiliation to the French social security system

Exclusion Criteria:

• Genetic form of alzheimer's disease

• Insufficient clinical and paraclinical information for the diagnosis of AD

• Anticholinesterase and/or memantine treatment or on stable doses for at least 3months

• Use of antidepressants, anxiolytics, hypnotics, neuroleptics, 15 days beforeinclusion

• Patient living in a nursing home

• Illiteracy or inability to perform psycho-behavioural tests

• Major physical or neurosensory problems that may interfere with the tests

• Initial contraindication to diagnostic lumbar puncture (LP) (spinal surgery, skininfection, haemostasis abnormality, intracranial hypertension, severe coagulationdisorders, curative anticoagulant therapy, severe liver failure)

• Refusal to perform a diagnostic lumbar puncture

• Contraindication to the use of E-Celsius: people weighing less than 40 kg, withintestinal disorders, with known swallowing disorders

• Patient deprived of liberty, by judicial or administrative decision;

• Major protected by law;

• Patient in a period of relative exclusion from another protocol or for whom themaximum annual compensation of €4500 has been reached;

• Refusal to participate in the protocol.