Accelerated Resolution Therapy for Early Maladaptive Grief

Last updated: September 22, 2025
Sponsor: Mayo Clinic
Overall Status: Active - Recruiting

Phase

N/A

Condition

N/A

Treatment

Information and Support

Accelerated Resolution Therapy

Clinical Study ID

NCT05624879
22-005315
R01AG077656
  • Ages > 60
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

The purpose study is to test the effects of accelerated resolution therapy (ART) on pre-loss grief and prolonged grief disorder among older adult family caregivers (FCGs). Additionally, to better understand predictors of response to ART, and cognitive processes that occur among grieving individuals following ART.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Primary caregiver of immediate family member who has a life expectancy of less than 12 months

  • Score of 30 or higher on the PG-12-R, indicating clinically significant pre-lossgrief

  • Denial of suicidal ideation or intent, with no evidence of psychotic behavior.

Exclusion

Exclusion Criteria:

  • Since becoming a family caregiver (FCG), they have engaged in another trauma basedpsychotherapeutic regimen (EMDR, prolonged exposure therapy, trauma focusedcognitive behavioral therapy) that could influence response to acceleratedresolution therapy (ART).

  • Self-reported or clinically assessed major psychiatric disorder (e.g., bipolardisorder, schizophrenia).

  • Score of > 2 on the adapted CAGE questionnaire indicating alcohol /drug dependence.

  • Cognitive impairment (SPMSQ > 4 errors).

Study Design

Total Participants: 440
Treatment Group(s): 2
Primary Treatment: Information and Support
Phase:
Study Start date:
November 17, 2023
Estimated Completion Date:
March 14, 2028

Study Description

Accelerated Resolution Therapy (ART) is an evidence-based treatment for post-traumatic distress in civilians and veterans that may be useful in alleviating maladaptive grief prior to bereavement and could prevent prolonged grief disorder following bereavement. Researchers are proposing to test the efficacy of ART, a low-risk, brief therapy with a strong theoretical rationale for treatment success in maladaptive grief and supported by the promising results of a recently completed preliminary trial. Additional aims of the study are to examine changes in cognitive appraisal and integration of loss following ART using a mixed methods approach and to evaluate personal, social, and psychological factors predictors of response.

During the proposed double blinded, randomized, controlled two arm clinical trial, older adult family caregivers will receive either ART or an educational program that is matched for time and attention. Each participant will receive four sessions of either the ART intervention or the control intervention. Data collection will occur at screening/enrollment (T1), at the end of the 4-session intervention period (T2) and at 6-months (T3) and 13-months post bereavement (T4). A subgroup of 20 participants randomly assigned to ART will participate in semi-structured interviews to enhance understanding of cognitive appraisal and integration of loss.

This trial will provide critical information on the efficacy of the ART intervention as a potential first-line treatment option for pre-loss grief and preventative option for prolonged grief disorder, and contribute new information about characteristics of individuals most likely to benefit from ART.

Connect with a study center

  • Mayo Clinic Arizona

    Phoenix, Arizona 85054
    United States

    Site Not Available

  • Mayo Clinic Arizona

    Phoenix 5308655, Arizona 5551752 85054
    United States

    Active - Recruiting

  • Suncoast Hospice

    Clearwater, Florida 33760
    United States

    Site Not Available

  • Mayo Clinic Florida

    Jacksonville, Florida 32224
    United States

    Site Not Available

  • Suncoast Hospice

    Clearwater 4151316, Florida 4155751 33760
    United States

    Active - Recruiting

  • Mayo Clinic Florida

    Jacksonville 4160021, Florida 4155751 32224
    United States

    Active - Recruiting

  • Mayo Clinic

    Rochester, Minnesota 55905
    United States

    Site Not Available

  • Mayo Clinic

    Rochester 5043473, Minnesota 5037779 55905
    United States

    Active - Recruiting

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