Effectiveness of Pulpotomy in the Management of Mature Permanent Tooth With Irreversible Pulpits

Phase

N/A

Condition

Acute And Chronic Dental Pain

Treatment

N/A

Clinical Study ID

NCT05622266

NFEC-2022-334

Ages 18-59
All Genders
Accepts Healthy Volunteers

Study Summary

This study is to evaluate the effectiveness of pulpotomy in mature permanent tooth with irreversible pulpits, and compare the clinical efficacy of pulpotomy and root canal therapy.

Eligibility Criteria

Inclusion

Inclusion Criteria: Intended to participate with this study, and provide informed assent/consent. Aged 18 and 59 years. At least one mature permanent teeth diagnosed as acute pulpitis or chronicpulpitis, and the teeth was in Nolla stage 9 and above by radiographic examination. To be prepared to appear for follow-up.

Exclusion

Exclusion Criteria: Allergic to any medications or materials necessary to complete the procedures. The teethwith severe coronal defect that find to be non-restorable. The teeth with full crownrestoration. The teeth with root fracture or vertical root fractures. Patients withperiodontitis. Patients who are undergoing orthodontic treatment. Patients with dentaldysplasia or other oral genetic disorders. Women who are pregnant or lactating, or womenwho plan to become pregnant in the subsequent 2 years. Patients with mental disorders. Patients with a history of systemic diseases that may alterimmune function.

Study Design

January 01, 2022

December 30, 2024

Study Description

At present, root canal therapy ( RCT ) is still the main treatment for mature teeth diagnosed as irreversible pulpitis, but the teeth after RCT become non-vital, losing the immune defense mechanism and regeneration potential of pulp, which is not conducive to the long-term preservation of teeth. The traditional view is that mature permanent teeth with irreversible pulpitis are not indications for pulpotomy. However, with the deepening of pulp biology research and the availability of new pulp capping materials, the effect of pulpotomy is more predictable. Recent studies have shown that pulpotomy for irreversible pulpitis teeth can achieve good results, however, there is a lack of high-quality randomized controlled clinical studies, and the effect of pulpotomy compared with RCT studies rarely reported. Therefore, this project intends to explore the curative effect of pulpotomy on mature permanent teeth with irreversible pulpitis, and analyze the influence of age, tooth position and other factors on its curative effect, broaden the indications of pulpotomy, and establish the indications and standardized operation process of pulpotomy for mature permanent teeth with irreversible pulpitis.

Connect with a study center

Nanfang Hospital, Southern Medical University
Guangzhou, Guangdong 510515
China
Active - Recruiting

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