Clinical Trial of GAIA-102 for Refractory/Relapse Neuroblastomas and Other Malignant Pediatric Solid Tumors

Inclusion Criteria:

1. Patients who have been confirmed to have the following malignant tumor byhistological examination

• cohort A : neuroblastoma or malignant solid tumor with pulmonary metastases,rhabdomyosarcoma, undifferentiated sarcoma, Ewing's sarcoma family,osteosarcoma, other cartilage sarcoma, nephroblastoma, hepatoblastoma, germcell neoplasma, other rare solid tumor (except brain tumor and brainmetastases) .

• cohort B : neuroblastoma.

• cohort C & D : neuroblastoma and other malignant solid tumors,rhabdomyosarcoma, Ewing's sarcoma family, hepatoblastoma.

2. Undergoing the following treatment.

• cohort A & B : Patients who have the resistance for more than two treatmentregimens, and the resistance for all standard regimens based on the guideline.

• cohort C & D : Patients with neuroblastoma who have completed the dinutuximabregimen and still have residual tumor. Patients with rhabdomyosarcoma, Ewing'ssarcoma family, hepatoblastoma who have the resistance for more than twotreatment regimens, and the resistance for all standard regimens based on theguideline.

3. Patients who have medical history for serious side effect , allergy reaction withregards to concomitant drugs.

4. Patients aged from 1years to 24 years at the time of obtaining consent.

5. Patients with performance status(PS) over 50 (Lansky Performance Status Score lessthan 16 years old) or (Karnofsky Performance Status over 16 years old) at the timeof obtaining consent.

Exclusion Criteria:

1. Patients with brain metastases.

2. Patients diagnosed with cancerous meningitis

3. Patients who received allogeneic hematopoietic stem cell transplant.

4. Patients with active autoimmune disease.