Clinical Course of Alcohol Use Disorder Recovery

Last updated: April 14, 2025
Sponsor: University of South Florida
Overall Status: Active - Recruiting

Phase

N/A

Condition

Alcohol Use Disorder

Alcohol Dependence

Substance Abuse

Treatment

Cognitive-Behavioral Treatment

Clinical Study ID

NCT05607290
1R01AA030005-01A1
  • Ages > 18
  • All Genders

Study Summary

The goal of this single-arm clinical trial is to better understand the ways in which individuals seeking treatment recover from Alcohol Use Disorder (AUD). The main aims are to:

  • To establish operational definitions of types of change in relation to National Institute on Alcohol Abuse and Alcoholism's (NIAAA) new definition of recovery, and to distinguish between treatment response, remission versus recovery, and relapse versus recurrence.

  • To describe patterns of recovery, including the frequency of within-person transitions between types of change in clinical course to better understand the dynamic nature of recovery.

  • To examine the predictive relationships between theoretically important cognitive, behavioral, and affective process variables and changes during recovery, with a focus on how people initiate versus maintain change.

Participants will:

  • Receive 12 weeks of psychotherapy for Alcohol Use Disorder

  • Complete brief assessments after each treatment session.

  • Complete brief assessments bi-weekly via phone for 1-year following treatment.

  • Complete in-person interviews at 3 or 6-month intervals post-treatment.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. current diagnosis of AUD (initial screening AUDIT ≥ 8, confirmed with diagnosticinterview),

  2. live within commuting distance of the program site,

  3. provide informed consent.

Exclusion

Exclusion Criteria:

  1. acute psychosis or severe cognitive impairment (assessed via Psychotic Module of theM.I.N.I and Mini-Mental State ≤ 23),

  2. current drug use diagnosis other than nicotine or marijuana use disorders,

  3. lack of sufficient familiarity with the English language to comprehend therecruitment and consent procedures,

  4. legally mandated to attend treatment

Study Design

Total Participants: 250
Treatment Group(s): 1
Primary Treatment: Cognitive-Behavioral Treatment
Phase:
Study Start date:
May 09, 2023
Estimated Completion Date:
August 31, 2027

Study Description

The aim of the current application is to examine the utility and validity of National Institute on Alcohol Abuse and Alcoholism's (NIAAA)new definition of recovery within the context of a novel theoretical model. The proposed study will recruit participants seeking treatment for Alcohol Use Disorder (AUD) from the community. Participants will complete a structured clinical interview and provide information on their current alcohol use and related behaviors. All participants will receive 12 weeks of AUD psychotherapy and complete brief assessments at the end of each treatment session and biweekly during the first 12-months post treatment. In addition, participants will complete in-person interviews at 3-month and 6-month intervals post-treatment for the duration of the study (for up to 24-54 months post treatment depending on time of enrollment). Findings from the proposed research have the potential to increase understanding of the dynamic nature of recovery and thereby improve clinical decision-making and generate future research. Specifically, our goal is to address the question of "Are the constructs of relapse, recurrence remission, or recovery useful heuristics for clinical practice and research, and if so, how?"

Connect with a study center

  • University of South Florida

    Tampa, Florida 33620
    United States

    Active - Recruiting

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