Phase
Condition
N/ATreatment
Sham Surgery
AAV-GAD Dose 1
AAV-GAD Dose 2
Clinical Study ID
Ages 25-85 All Genders
Study Summary
Eligibility Criteria
Inclusion
Inclusion Criteria:
Confirmed Parkinson's Disease
Levodopa responsiveness for at least 12 months
UPDRS Part 3 score of ≥25 points in the "off" state
Exclusion
Exclusion Criteria:
Past history of brain surgery to treat Parkinson's Disease
Any history of cerebral insult or central nervous system infection
Atypical Parkinson's Disease
Focal or lateralized neurologic deficits
Evidence of significant medical or psychiatric disorders
Cognitive impairment as defined by Montreal Cognitive Assessment (MoCA)≤20
Beck Depression Inventory-II score of ≥ 20
Study Design
Study Description
Connect with a study center
Yale University - Yale New Haven Hospital
New Haven, Connecticut 06510
United StatesSite Not Available
Henry Ford West Bloomfield Hospital
West Bloomfield, Michigan 48322
United StatesSite Not Available
Columbia University Irving Medical Center
New York, New York 10032
United StatesSite Not Available
Weill Cornell Medicine
New York, New York 10021
United StatesSite Not Available
Thomas Jefferson University
Philadelphia, Pennsylvania 19107
United StatesSite Not Available
West Virginia University
Morgantown, West Virginia 26506
United StatesSite Not Available
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