Efficacy and Safety of Tezepelumab in Patients With Eosinophilic Esophagitis

Inclusion Criteria:

1. Participant must be 12 to 80 years of age inclusive, at the time of signing theinformed consent/assent.

2. Weight ≥ 40 kg at Visit 1

3. Established diagnosis of EoE with a previous EGD and esophageal biopsy confirming adiagnosis of EoE.

4. Participants who have symptomatic EoE as defined by a history of on average at least 2 episodes of dysphagia (any severity of food going down slowly or being stuck inthe throat) per week in the 4 weeks prior to Visit 1.

5. Must remain on a stabilized diet for at least 8 weeks prior to Visit 1 and duringthe course of the study (stable diet is defined as no initiation of single ormultiple elimination diets or reintroduction of previously eliminated food groups).

6. May be on any background PPI and/or STC, during the course of the study, as long asbackground medications have been stable for at least 8 weeks prior to thescreening/run-in period (Visit 1) and there is agreement not to change backgroundmedication or dosage unless medically indicated, during the screening/run-in andtreatment period.

7. Participants currently on leukotriene inhibitors and/or steroid treatments forasthma or allergies that are inhaled or administered intranasally, must report astable dose for at least 4 weeks prior to the screening/run-in period (Visit 1).

8. If a medication for EoE (for example PPI and/or STC) is discontinued prior to thescreening/run-in, there should be a washout period of at least 8 weeks prior toVisit 1. Discontinuation of any marketed biologic (monoclonal or polyclonalantibody) should have a washout period of 4 months or 5 half-lives prior to Visit 1,whichever is longer.

9. Participants should have previously documented standard of care treatment, whichcould include PPI and/or STC and/or diet.

Exclusion Criteria:

1. Other gastrointestinal disorders such as active Helicobacter pylori infection,history of achalasia, esophageal varices, Crohn's disease, ulcerative colitis,inflammatory bowel disease, celiac disease, eosinophilic enteritis, colitis,diverticulitis, irritable bowel syndrome, or other clinically significantgastrointestinal conditions as per Investigator discretion.

2. Esophageal stricture that prevents the easy passage of a standard endoscope or anycritical esophageal stricture that requires dilation at screening.

3. Use of a feeding tube, or having a pattern of not eating solid food >3 days of week.Solid food is defined as food that requires chewing before swallowing.

4. Hypereosinophilic syndrome

5. EGPA vasculitis

6. Esophageal dilation performed within 8 weeks prior to screening.