Effect of Synbiotic as an Adjuvant Therapy in the Treatment of Parkinson's Disease

Last updated: April 7, 2025
Sponsor: Tanta University
Overall Status: Active - Recruiting

Phase

3

Condition

Parkinson's Disease

Dyskinesias

Treatment

Lactobacillus acidophilus 10 billion colony forming unit (CFU) and prebiotic fibers

Clinical Study ID

NCT05576818
Synbiotics Parkinson's disease
  • Ages 45-65
  • All Genders

Study Summary

This study aims to investigate the possible efficacy and safety of synbiotic preparation of Lactobacillus acidophilus probiotic with prebiotic fibers as an adjuvant therapy in the treatment of Parkinson's disease

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Age between 45 and 65 years old

  • Both sexes

  • Patients with Parkinson's disease on dopamine replacement therapy

  • Modified Hoehn and Yahr stage, MHY 1-4

Exclusion

Exclusion Criteria:

  • Patients who are currently using or used antibiotics therapy in the preceding month

  • Patients who are currently using or used other probiotic products in the precedingtwo weeks

  • Patients scheduled to undergo GIT surgery or those underwent GIT surgery

  • Patients with Known allergy to probiotics

  • Patients receiving artificial enteral or intravenous nutrition

  • Patients with depression and/or psychosis

  • Patients taking antioxidant and/or anti-inflammatory medications

  • Patients with Hyperthyroidism

  • Patients with inflammatory condition and/or condition involving oxidative stress

  • Smokers

  • Modified Hoehn & Yahr stage MHY 5

Study Design

Total Participants: 66
Treatment Group(s): 1
Primary Treatment: Lactobacillus acidophilus 10 billion colony forming unit (CFU) and prebiotic fibers
Phase: 3
Study Start date:
June 30, 2022
Estimated Completion Date:
June 30, 2025

Connect with a study center

  • Tanta University

    Tanta, El Gharbia
    Egypt

    Active - Recruiting

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