Search for BIO Diagnostic and Prognostic Markers in Adult VAScularitis

Last updated: February 29, 2024
Sponsor: University Hospital, Tours
Overall Status: Active - Recruiting

Phase

N/A

Condition

Dermatomyositis (Connective Tissue Disease)

Lupus

Collagen Vascular Diseases

Treatment

Sampling

Clinical Study ID

NCT05565885
DR220193-BIOVAS
  • Ages > 16
  • All Genders

Study Summary

To date, there are no reliable diagnostic blood markers of adult vasculitis. To date, the diagnosis of vasculitis is based on invasive procedure, biopsy of affected tissues potentially at risk of complication . In addition, there are no reliable biomarkers to predict the evolution of vasculitis (relapse, refractory form ...) necessary for the management of patients (type of treatment, duration ..)

Prospective study, monocentric (CHU de Tours), non-interventional, aimed at finding diagnostic and prognostic biomarkers (both metabolomic and immunologic) in adult vasculitis patients.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Age > 16 years
  • Active vasculitis, new diagnosis or relapse
  • IgA vasculitis
  • ANCA vasculitis
  • Giant cell arteritis

Exclusion

Exclusion Criteria:

  • Person who has objected to the processing of data
  • Pregnant woman
  • Patient positive for HIV, HBV, HCV
  • Treatment in the previous month with corticosteroids, immunosuppressive drugs orbiotherapy.
  • Patient unable to understand the information leaflet
  • Adult under guardianship or curatorship

Study Design

Total Participants: 225
Treatment Group(s): 1
Primary Treatment: Sampling
Phase:
Study Start date:
November 22, 2022
Estimated Completion Date:
December 31, 2037

Study Description

Specimen will be collected at diagnosis, month 1, month 3, and month12 and at the time of a possible relapse. 14 ml of additional blood during a blood puncture made for routine care will be collected at each visit as well as clinical data.

Connect with a study center

  • University hospital

    Tours, 37044
    France

    Active - Recruiting

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