A Study of the Efficacy, Safety, and Pharmacokinetics (PK) of the Port Delivery System With Ranibizumab (PDS) in Chinese Participants With Neovascular Age-related Macular Degeneration (nAMD)

Inclusion Criteria:

• Initial diagnosis of nAMD within 9 months prior to the screening visit

• Previous treatment with at least three anti-vascular endothelial growth factor (VEGF) IVT injections for nAMD per standard of care within 6 months prior to thescreening visit

• Demonstrated response to prior anti-VEGF IVT treatment since diagnosis

• Availability of historical VA data prior to the first anti-VEGF treatment for nAMDup to the screening visit

• BCVA of 34 letters or better (20/200 or better approximate Snellen equivalent),using Early Treatment Diabetic Retinopathy Study (ETDRS) chart at a startingdistance of 4 meters

• All subtypes of nAMD lesions are permissible

• Sufficiently clear ocular media and adequate pupillary dilation to allow foranalysis and grading by the central reading center of fundus photography (FP),fluorescein angiography (FA), indocyanine green angiography (ICGA), fundusautofluorescence (FAF), and optical coherence tomography (OCT) images

Exclusion Criteria:

A. Prior Ocular Treatment Study Eye

• History of vitrectomy surgery, submacular surgery, or other surgical intervention,all for AMD

• Prior treatment with Visudyne, external-beam radiation therapy, or transpupillarythermotherapy

• Previous treatment with corticosteroid IVT injection

• Previous intraocular device implantation (not including intraocular lens implants)

• Previous laser (any type) used for age-related macular degeneration (AMD) treatment

• Treatment with anti-VEGF agents other than ranibizumab within 1 month prior to therandomization visit

• Prior treatment with intravitreal treatments for geographic atrophy

• Concurrent conjunctival, Tenon's capsule, and/or scleral condition in thesupero-temporal quadrant of the eye that may affect the implantation, subsequenttissue coverage, and refill-exchange procedure of the PDS implant

Either Eye

• Prior treatment with brolucizumab

• Prior gene therapy for nAMD or other ocular diseases

• Previous participation in any ocular disease studies of investigational drugs and/ordevices, within 3 months or five elimination half-lives of the investigationaltherapy, whichever is longer, preceding the screening visit

B. Choroidal Neovascularization (CNV) Lesion Characteristics

Study Eye

• Subretinal hemorrhage that involves the center of the fovea, if the hemorrhage isgreater than 0.5 disc area (1.27 millimeter square [mm^2]) in size at screening

• Subfoveal fibrosis or subfoveal atrophy

Either Eye • CNV due to other causes, such as ocular histoplasmosis, trauma, central serous chorio-retinopathy, or pathologic myopia

C. Concurrent Ocular Conditions Study Eye

• Retinal pigment epithelial tear

• Any concurrent intraocular condition

• Active intraocular inflammation (grade trace or above)

• History of vitreous hemorrhage

• History of rhegmatogenous retinal detachment

• History of rhegmatogenous retinal tears or peripheral retinal breaks within 3 monthsprior to the randomization visit

• History of pars plana vitrectomy surgery

• Aphakia or absence of the posterior capsule

• Spherical equivalent of the refractive error demonstrating more than 8 diopters ofmyopia

• Preoperative refractive error that exceeds 8 diopters of myopia, for participantswho have undergone prior refractive or cataract surgery

• Intraocular surgery (including cataract surgery) within 3 months preceding therandomization visit

• Uncontrolled ocular hypertension or glaucoma

• History of glaucoma-filtering surgery, tube shunts, or microinvasive glaucomasurgery

• History of corneal transplant

Fellow (Non-Study) Eye

• Non-functioning fellow eye

Either Eye

• Any history of uveitis

• Active infectious conjunctivitis, keratitis, scleritis, or endophthalmitis