Testing the Addition of the AKT Inhibitor, Ipatasertib, to Treatment With the Hormonal Agent Megestrol Acetate for Recurrent or Metastatic Endometrial Cancers

Last updated: July 2, 2025
Sponsor: National Cancer Institute (NCI)
Overall Status: Active - Not Recruiting

Phase

1/2

Condition

Adenocarcinoma

Endometrial Cancer

Treatment

Magnetic Resonance Imaging

Biospecimen Collection

Ipatasertib

Clinical Study ID

NCT05538897
NCI-2022-07505
NRG-GY028
U10CA180868
NCI-2022-07505
  • Ages > 18
  • Female

Study Summary

This phase Ib/II trial tests the safety, side effects, best dose, and effectiveness of the combination of ipatasertib with megestrol acetate to megestrol acetate alone in patients with endometrial cancer that has come back (recurrent) or has spread to other places in the body (metastatic). Ipatasertib may stop the growth of tumor cells and may kill them by blocking some of the enzymes needed for cell growth. Megestrol acetate lowers the amount of estrogen and also blocks the use of estrogen made by the body. This may help stop the growth of tumor cells that need estrogen to grow. The combination of ipatasertib and megestrol acetate may be more effective in treating endometrial cancer than megestrol acetate alone.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Patients must have grade 1 or 2 recurrent or metastatic endometrioid endometrialcancer

  • Patients must have measurable disease according to RECIST version (v)1.1. Measurabledisease is defined as at least one lesion that can be accurately measured in atleast one dimension (longest diameter to be recorded). Each lesion must be >= 10 mmwhen measured by CT or MRI. Lymph nodes must be >= 15 mm in short axis when measuredby CT or MRI. Previously irradiated lesions can be considered as measurable diseaseonly if progressive disease has been unequivocally documented at that site sinceradiation

  • Patients may have received unlimited prior lines of therapy. If patient receivedprior hormonal therapy (e.g., megestrol acetate, medroxyprogesterone acetate,aromatase inhibitor, tamoxifen, fulvestrant) it must have completed at least 6months prior to registration

  • Age >= 18

  • Eastern Cooperative Oncology Group (ECOG) Performance Status of 0, 1 or 2

  • Platelets >= 100,000/mcl within 14 days prior to registration

  • Absolute neutrophil count (ANC) >= 1,500/mcl within 14 days prior to registration

  • Hemoglobin >= 9 g/dL within 14 days prior to registration

  • Glomerular filtration rate (GFR) >= 60 mL/min/1.73m^2 measured using Cockcroft-Gaultequation or the estimated glomerular filtration rate from the Modification of Dietin Renal Disease Study within 14 days prior to registration

  • Total bilirubin =< 1.5 x the upper limit of normal (ULN) within 14 days prior toregistration

  • Patients with known Gilbert syndrome who have bilirubin =< 3 x ULN may beenrolled

  • Aspartate aminotransferase (AST) (serum glutamic oxaloacetic transaminase [SGOT])/alanine aminotransferase (ALT) (serum glutamate pyruvate transaminase [SGPT]) =< 3 x institutional ULN within 14 days prior to registration

  • Albumin >= 3 g/dL within 14 days prior to registration

  • Patients with known history or current symptoms of cardiac disease, or history oftreatment with cardiotoxic agents, should have a clinical risk assessment of cardiacfunction using the New York Heart Association Functional Classification. To beeligible for this trial, patients should be class 2B or better

  • The effects of ipatasertib on the developing human fetus are unknown. For thisreason and because AKT inhibitor agents as well as other therapeutic agents used inthis trial are known to be teratogenic, participants of child-bearing potential mustagree to use adequate contraception (hormonal or barrier method of birth control;abstinence) during study therapy and for 28 days following the last dose of studytherapy. Should a participant become pregnant or suspect pregnancy whileparticipating in this study, they should inform their treating physician immediately

  • Patients with a prior or concurrent malignancy whose natural history or treatmentdoes not have the potential to interfere with the safety or efficacy assessment ofthe investigational regimen are eligible for this trial

  • For patients with known human immunodeficiency virus (HIV), hepatitis B virus (HBV),and/or hepatitis C virus (HCV) infection:

  • HIV-infected patients on effective anti-retroviral therapy with undetectableviral load within 6 months of registration are eligible for this trial

  • Patients with evidence of chronic hepatitis B virus (HBV) infection must havean undetectable HBV viral load on suppressive therapy, if indicated

  • Patients with a history of hepatitis C virus (HCV) infection must have beentreated and cured. For patients with HCV infection who are currently ontreatment, they are eligible if they have an undetectable HCV viral load

  • Patients with treated brain metastases are eligible if follow-up brain imaging aftercentral nervous system (CNS)-directed therapy shows no evidence of progression

  • Patients must be able to swallow and retain oral medications and not havegastrointestinal illnesses that would preclude absorption of megestrol acetate oripatasertib as judged by the treating physician

  • The patient or a legally authorized representative must provide study-specificinformed consent prior to study entry and, for patients treated in the United States (U.S.), authorization permitting release of personal health information

Exclusion

Exclusion Criteria:

  • Patients who have had prior treatment with an AKT inhibitor (Prior treatment withPI3K or mTOR inhibitors is allowed)

  • Patients who have received treatment with strong CYP3A inhibitors or inducers within 14 days or 5 drug-elimination half-lives, whichever is longer, prior to studyregistration

  • Because the lists of these agents are constantly changing, it is important toregularly consult a frequently-updated medical reference. As part of theenrollment/informed consent procedures, the patient will be counseled on therisk of interactions with other agents, and what to do if new medications needto be prescribed or if the patient is considering a new over-the-countermedicine or herbal product

  • Patients with diabetes either requiring insulin therapy or with a baseline fastingglucose > 160 mg/dL and/or high glycosylated hemoglobin A1c (HbA1c) (> 8),suggesting poorly controlled diabetes. Fasting is defined as abstaining from foodand drink (with the exception of water) for at least 8 hours

  • Patients who require chronic corticosteroid therapy of > 10 mg of prednisone per dayor an equivalent dose of other anti-inflammatory corticosteroids orimmunosuppressant agents for a chronic disease

  • Patients with grade 2 or greater uncontrolled or untreated hypercholesterolemia (> 300 mg/dL) or hypertriglyceridemia (> 300 mg/dL)

  • Patients with a history of known or active inflammatory bowel disease (e.g., Crohndisease and ulcerative colitis) or active bowel inflammation (e.g., diverticulitis)

  • Patients with a history of or presence of an abnormal electrocardiogram (ECG) thatis clinically significant in the investigator's opinion (including complete leftbundle branch block, second- or third-degree heart block, or evidence of priormyocardial infarction)

  • Patients with known clinically significant history of liver disease consistent withChild-Pugh class B or C, including active viral or other hepatitis, current drug oralcohol abuse, or cirrhosis

  • Patients with lung disease: Grade 2 or greater pneumonitis, grade 2 or greaterinterstitial lung disease, idiopathic pulmonary fibrosis, cystic fibrosis,aspergillosis, active tuberculosis, or history of opportunistic infections (pneumocystis pneumonia or cytomegalovirus pneumonia) within the past 6 months

  • No active infection requiring parenteral antibiotics

  • Women who are pregnant or unwilling to discontinue nursing

Study Design

Total Participants: 96
Treatment Group(s): 5
Primary Treatment: Magnetic Resonance Imaging
Phase: 1/2
Study Start date:
March 31, 2023
Estimated Completion Date:
January 31, 2027

Study Description

PRIMARY OBJECTIVES:

I. Determine the toxicity of ipatasertib in combination with megestrol acetate in women with metastatic grade 1-2 endometrioid endometrial cancer and establish the recommended phase II dose. (Phase I) II. Compare the progression free survival of the combination of ipatasertib with megestrol acetate to megestrol acetate alone among women with metastatic grade 1-2 endometrioid adenocarcinoma of the endometrium. (Phase II) III. Compare the toxicity of the combination of ipatasertib with megestrol acetate to megestrol acetate alone. (Phase II)

SECONDARY OBJECTIVES:

I. Compare objective response rate per Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 between the two arms.

II. Examine the pharmacokinetics of ipatasertib + megestrol acetate to assess potential drug-drug interactions.

III. Assess the association between biomarkers and response to therapy.

EXPLORATORY OBJECTIVE:

I. Explore whether pS6/total S6 and pPRAS40/total PRAS40 expression is impacted by the use of ipatasertib and megestrol acetate.

OUTLINE: This is a phase Ib, dose de-escalation study of ipatasertib followed by a phase II study.

PHASE Ib: Patients receive megestrol acetate orally (PO) once daily (QD) on days 1-28 and ipatasertib PO QD on days 1-21 of each cycle. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. Patients undergo a computed tomography (CT) or magnetic resonance imaging (MRI) during screening, on study, and during follow-up. Patients also undergo collection of blood samples throughout the trial.

PHASE II: Patients are randomized to 1 of 2 arms.

ARM I: Patients receive megestrol acetate PO QD on days 1-28 of each cycle. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. Patients undergo a CT or MRI during screening, on study, and during follow-up. Patients also undergo collection of blood samples throughout the trial.

ARM II: Patients receive megestrol acetate PO QD on days 1-28 and ipatasertib PO QD on days 1-21 of each cycle. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. Patients undergo a CT or MRI during screening, on study, and during follow-up. Patients also undergo collection of blood samples throughout the trial.

After completion of study treatment, patients are followed up at 30 days for the phase I study. Patients are followed up every 3 months for 2 years, then every 6 months for 3 years for the phase II study.

Connect with a study center

  • Banner University Medical Center - Tucson

    Tucson, Arizona 85719
    United States

    Site Not Available

  • University of Arizona Cancer Center-North Campus

    Tucson, Arizona 85719
    United States

    Site Not Available

  • Highlands Oncology Group - Fayetteville

    Fayetteville, Arkansas 72703
    United States

    Site Not Available

  • Highlands Oncology Group - Rogers

    Rogers, Arkansas 72758
    United States

    Site Not Available

  • Highlands Oncology Group

    Springdale, Arkansas 72762
    United States

    Site Not Available

  • University of California Davis Comprehensive Cancer Center

    Sacramento, California 95817
    United States

    Site Not Available

  • UCHealth University of Colorado Hospital

    Aurora, Colorado 80045
    United States

    Site Not Available

  • University of Colorado Hospital

    Aurora, Colorado 80045
    United States

    Active - Recruiting

  • University of Florida Health Science Center - Gainesville

    Gainesville, Florida 32610
    United States

    Site Not Available

  • Sarasota Memorial Hospital-Venice

    N. Venice, Florida 34275
    United States

    Site Not Available

  • First Physicians Group-Sarasota

    Sarasota, Florida 34239
    United States

    Site Not Available

  • Florida Cancer Specialists - Sarasota Downtown

    Sarasota, Florida 34236
    United States

    Site Not Available

  • Sarasota Memorial Hospital

    Sarasota, Florida 34239
    United States

    Site Not Available

  • Florida Cancer Specialists - Venice Healthpark

    Venice, Florida 34292
    United States

    Active - Recruiting

  • Florida Cancer Specialists - Venice Pinebrook

    Venice, Florida 34275
    United States

    Site Not Available

  • Augusta University Medical Center

    Augusta, Georgia 30912
    United States

    Site Not Available

  • Saint Alphonsus Cancer Care Center-Boise

    Boise, Idaho 83706
    United States

    Site Not Available

  • Saint Luke's Cancer Institute - Boise

    Boise, Idaho 83712
    United States

    Site Not Available

  • Saint Alphonsus Cancer Care Center-Caldwell

    Caldwell, Idaho 83605
    United States

    Site Not Available

  • Kootenai Health - Coeur d'Alene

    Coeur d'Alene, Idaho 83814
    United States

    Site Not Available

  • Saint Luke's Cancer Institute - Fruitland

    Fruitland, Idaho 83619
    United States

    Site Not Available

  • Saint Luke's Cancer Institute - Meridian

    Meridian, Idaho 83642
    United States

    Site Not Available

  • Saint Alphonsus Cancer Care Center-Nampa

    Nampa, Idaho 83687
    United States

    Site Not Available

  • Saint Luke's Cancer Institute - Nampa

    Nampa, Idaho 83687
    United States

    Site Not Available

  • Kootenai Clinic Cancer Services - Post Falls

    Post Falls, Idaho 83854
    United States

    Site Not Available

  • Kootenai Clinic Cancer Services - Sandpoint

    Sandpoint, Idaho 83864
    United States

    Site Not Available

  • Northwestern University

    Chicago, Illinois 60611
    United States

    Site Not Available

  • University of Illinois

    Chicago, Illinois 60612
    United States

    Site Not Available

  • Carle at The Riverfront

    Danville, Illinois 61832
    United States

    Site Not Available

  • Northwestern Medicine Cancer Center Kishwaukee

    DeKalb, Illinois 60115
    United States

    Site Not Available

  • Cancer Care Specialists of Illinois - Decatur

    Decatur, Illinois 62526
    United States

    Site Not Available

  • Decatur Memorial Hospital

    Decatur, Illinois 62526
    United States

    Site Not Available

  • Carle Physician Group-Effingham

    Effingham, Illinois 62401
    United States

    Site Not Available

  • Crossroads Cancer Center

    Effingham, Illinois 62401
    United States

    Site Not Available

  • Northwestern Medicine Cancer Center Delnor

    Geneva, Illinois 60134
    United States

    Site Not Available

  • Northwestern Medicine Grayslake Outpatient Center

    Grayslake, Illinois 60030
    United States

    Site Not Available

  • Northwestern Medicine Lake Forest Hospital

    Lake Forest, Illinois 60045
    United States

    Site Not Available

  • Carle Physician Group-Mattoon/Charleston

    Mattoon, Illinois 61938
    United States

    Site Not Available

  • Cancer Care Center of O'Fallon

    O'Fallon, Illinois 62269
    United States

    Site Not Available

  • Northwestern Medicine Orland Park

    Orland Park, Illinois 60462
    United States

    Site Not Available

  • Memorial Medical Center

    Springfield, Illinois 62781
    United States

    Active - Recruiting

  • Southern Illinois University School of Medicine

    Springfield, Illinois 62702
    United States

    Site Not Available

  • Springfield Clinic

    Springfield, Illinois 62702
    United States

    Site Not Available

  • Springfield Memorial Hospital

    Springfield, Illinois 62781
    United States

    Site Not Available

  • Carle Cancer Center

    Urbana, Illinois 61801
    United States

    Site Not Available

  • Northwestern Medicine Cancer Center Warrenville

    Warrenville, Illinois 60555
    United States

    Site Not Available

  • IU Health North Hospital

    Carmel, Indiana 46032
    United States

    Site Not Available

  • Parkview Regional Medical Center

    Fort Wayne, Indiana 46845
    United States

    Site Not Available

  • Goshen Center for Cancer Care

    Goshen, Indiana 46526
    United States

    Site Not Available

  • Indiana University/Melvin and Bren Simon Cancer Center

    Indianapolis, Indiana 46202
    United States

    Site Not Available

  • Memorial Hospital of South Bend

    South Bend, Indiana 46601
    United States

    Site Not Available

  • Mission Cancer and Blood - Ankeny

    Ankeny, Iowa 50023
    United States

    Active - Recruiting

  • UI Health Care Mission Cancer and Blood - Ankeny Clinic

    Ankeny, Iowa 50023
    United States

    Site Not Available

  • Iowa Methodist Medical Center

    Des Moines, Iowa 50309
    United States

    Site Not Available

  • Mission Cancer and Blood - Des Moines

    Des Moines, Iowa 50309
    United States

    Active - Recruiting

  • UI Health Care Mission Cancer and Blood - Des Moines Clinic

    Des Moines, Iowa 50309
    United States

    Site Not Available

  • University of Iowa/Holden Comprehensive Cancer Center

    Iowa City, Iowa 52242
    United States

    Site Not Available

  • University of Kansas Cancer Center

    Kansas City, Kansas 66160
    United States

    Site Not Available

  • University of Kansas Hospital-Indian Creek Campus

    Overland Park, Kansas 66211
    United States

    Site Not Available

  • University of Kansas Hospital-Westwood Cancer Center

    Westwood, Kansas 66205
    United States

    Site Not Available

  • Harold Alfond Center for Cancer Care

    Augusta, Maine 04330
    United States

    Site Not Available

  • Maine Medical Center- Scarborough Campus

    Scarborough, Maine 04074
    United States

    Active - Recruiting

  • MaineHealth Maine Medical Center- Scarborough

    Scarborough, Maine 04074
    United States

    Site Not Available

  • Walter Reed National Military Medical Center

    Bethesda, Maryland 20889-5600
    United States

    Site Not Available

  • University of Michigan Comprehensive Cancer Center

    Ann Arbor, Michigan 48109
    United States

    Site Not Available

  • Bronson Battle Creek

    Battle Creek, Michigan 49017
    United States

    Site Not Available

  • Corewell Health Grand Rapids Hospitals - Butterworth Hospital

    Grand Rapids, Michigan 49503
    United States

    Site Not Available

  • Trinity Health Grand Rapids Hospital

    Grand Rapids, Michigan 49503
    United States

    Site Not Available

  • Ascension Borgess Cancer Center

    Kalamazoo, Michigan 49009
    United States

    Site Not Available

  • Bronson Methodist Hospital

    Kalamazoo, Michigan 49007
    United States

    Site Not Available

  • West Michigan Cancer Center

    Kalamazoo, Michigan 49007
    United States

    Site Not Available

  • Trinity Health Muskegon Hospital

    Muskegon, Michigan 49444
    United States

    Site Not Available

  • Corewell Health Lakeland Hospitals - Niles Hospital

    Niles, Michigan 49120
    United States

    Site Not Available

  • Cancer and Hematology Centers of Western Michigan - Norton Shores

    Norton Shores, Michigan 49444
    United States

    Site Not Available

  • Corewell Health Reed City Hospital

    Reed City, Michigan 49677
    United States

    Site Not Available

  • Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center

    Saint Joseph, Michigan 49085
    United States

    Site Not Available

  • Corewell Health Lakeland Hospitals - Saint Joseph Hospital

    Saint Joseph, Michigan 49085
    United States

    Site Not Available

  • Munson Medical Center

    Traverse City, Michigan 49684
    United States

    Site Not Available

  • University of Michigan Health - West

    Wyoming, Michigan 49519
    United States

    Site Not Available

  • Mercy Hospital

    Coon Rapids, Minnesota 55433
    United States

    Site Not Available

  • Fairview Southdale Hospital

    Edina, Minnesota 55435
    United States

    Site Not Available

  • Abbott-Northwestern Hospital

    Minneapolis, Minnesota 55407
    United States

    Site Not Available

  • University of Minnesota/Masonic Cancer Center

    Minneapolis, Minnesota 55455
    United States

    Site Not Available

  • Park Nicollet Clinic - Saint Louis Park

    Saint Louis Park, Minnesota 55416
    United States

    Site Not Available

  • Regions Hospital

    Saint Paul, Minnesota 55101
    United States

    Site Not Available

  • United Hospital

    Saint Paul, Minnesota 55102
    United States

    Site Not Available

  • Minnesota Oncology Hematology PA-Woodbury

    Woodbury, Minnesota 55125
    United States

    Site Not Available

  • MU Health - University Hospital/Ellis Fischel Cancer Center

    Columbia, Missouri 65212
    United States

    Site Not Available

  • MU Health Care Goldschmidt Cancer Center

    Jefferson City, Missouri 65109
    United States

    Site Not Available

  • University of Kansas Cancer Center - North

    Kansas City, Missouri 64154
    United States

    Site Not Available

  • Mercy Hospital Saint Louis

    Saint Louis, Missouri 63141
    United States

    Site Not Available

  • Mercy Hospital South

    Saint Louis, Missouri 63128
    United States

    Site Not Available

  • Mercy Hospital Springfield

    Springfield, Missouri 65804
    United States

    Site Not Available

  • Community Hospital of Anaconda

    Anaconda, Montana 59711
    United States

    Site Not Available

  • Billings Clinic Cancer Center

    Billings, Montana 59101
    United States

    Site Not Available

  • Bozeman Health Deaconess Hospital

    Bozeman, Montana 59715
    United States

    Site Not Available

  • Benefis Sletten Cancer Institute

    Great Falls, Montana 59405
    United States

    Site Not Available

  • Community Medical Center

    Missoula, Montana 59804
    United States

    Site Not Available

  • Cooper Hospital University Medical Center

    Camden, New Jersey 08103
    United States

    Site Not Available

  • University of New Mexico Cancer Center

    Albuquerque, New Mexico 87106
    United States

    Site Not Available

  • Montefiore Medical Center - Moses Campus

    Bronx, New York 10467
    United States

    Site Not Available

  • Montefiore Medical Center-Einstein Campus

    Bronx, New York 10461
    United States

    Site Not Available

  • Montefiore Medical Center-Weiler Hospital

    Bronx, New York 10461
    United States

    Site Not Available

  • University of Rochester

    Rochester, New York 14642
    United States

    Site Not Available

  • State University of New York Upstate Medical University

    Syracuse, New York 13210
    United States

    Site Not Available

  • UNC Lineberger Comprehensive Cancer Center

    Chapel Hill, North Carolina 27599
    United States

    Site Not Available

  • Carolinas Medical Center/Levine Cancer Institute

    Charlotte, North Carolina 28203
    United States

    Site Not Available

  • Atrium Health Cabarrus/LCI-Concord

    Concord, North Carolina 28025
    United States

    Site Not Available

  • Summa Health System - Akron Campus

    Akron, Ohio 44304
    United States

    Site Not Available

  • UHHS-Chagrin Highlands Medical Center

    Beachwood, Ohio 44122
    United States

    Site Not Available

  • Miami Valley Hospital South

    Centerville, Ohio 45459
    United States

    Site Not Available

  • Geauga Hospital

    Chardon, Ohio 44024
    United States

    Site Not Available

  • Good Samaritan Hospital - Cincinnati

    Cincinnati, Ohio 45220
    United States

    Site Not Available

  • Case Western Reserve University

    Cleveland, Ohio 44106
    United States

    Site Not Available

  • Cleveland Clinic Foundation

    Cleveland, Ohio 44195
    United States

    Site Not Available

  • Ohio State University Comprehensive Cancer Center

    Columbus, Ohio 43210
    United States

    Site Not Available

  • Riverside Methodist Hospital

    Columbus, Ohio 43214
    United States

    Site Not Available

  • Miami Valley Hospital

    Dayton, Ohio 45409
    United States

    Site Not Available

  • Miami Valley Hospital North

    Dayton, Ohio 45415
    United States

    Site Not Available

  • Atrium Medical Center-Middletown Regional Hospital

    Franklin, Ohio 45005-1066
    United States

    Site Not Available

  • Miami Valley Cancer Care and Infusion

    Greenville, Ohio 45331
    United States

    Site Not Available

  • UH Seidman Cancer Center at Lake Health Mentor Campus

    Mentor, Ohio 44060
    United States

    Site Not Available

  • Upper Valley Medical Center

    Troy, Ohio 45373
    United States

    Site Not Available

  • UH Seidman Cancer Center at Saint John Medical Center

    Westlake, Ohio 44145
    United States

    Site Not Available

  • University of Oklahoma Health Sciences Center

    Oklahoma City, Oklahoma 73104
    United States

    Site Not Available

  • Oklahoma Cancer Specialists and Research Institute-Tulsa

    Tulsa, Oklahoma 74146
    United States

    Site Not Available

  • Saint Alphonsus Cancer Care Center-Ontario

    Ontario, Oregon 97914
    United States

    Site Not Available

  • Providence Portland Medical Center

    Portland, Oregon 97213
    United States

    Site Not Available

  • Providence Saint Vincent Medical Center

    Portland, Oregon 97225
    United States

    Site Not Available

  • Jefferson Hospital

    Jefferson Hills, Pennsylvania 15025
    United States

    Site Not Available

  • Forbes Hospital

    Monroeville, Pennsylvania 15146
    United States

    Site Not Available

  • NRG Oncology

    Philadelphia, Pennsylvania 19103
    United States

    Site Not Available

  • Thomas Jefferson University Hospital

    Philadelphia, Pennsylvania 19107
    United States

    Site Not Available

  • Allegheny General Hospital

    Pittsburgh, Pennsylvania 15212
    United States

    Site Not Available

  • West Penn Hospital

    Pittsburgh, Pennsylvania 15224
    United States

    Site Not Available

  • Wexford Health and Wellness Pavilion

    Wexford, Pennsylvania 15090
    United States

    Site Not Available

  • Asplundh Cancer Pavilion

    Willow Grove, Pennsylvania 19090
    United States

    Site Not Available

  • Women and Infants Hospital

    Providence, Rhode Island 02905
    United States

    Site Not Available

  • Medical University of South Carolina

    Charleston, South Carolina 29425
    United States

    Site Not Available

  • Vanderbilt University/Ingram Cancer Center

    Nashville, Tennessee 37232
    United States

    Site Not Available

  • Parkland Memorial Hospital

    Dallas, Texas 75235
    United States

    Site Not Available

  • UT Southwestern/Simmons Cancer Center-Dallas

    Dallas, Texas 75390
    United States

    Site Not Available

  • UT Southwestern/Simmons Cancer Center-Fort Worth

    Fort Worth, Texas 76104
    United States

    Site Not Available

  • Lyndon Baines Johnson General Hospital

    Houston, Texas 77026-1967
    United States

    Site Not Available

  • M D Anderson Cancer Center

    Houston, Texas 77030
    United States

    Site Not Available

  • Memorial Hermann Texas Medical Center

    Houston, Texas 77030
    United States

    Site Not Available

  • UT Southwestern Clinical Center at Richardson/Plano

    Richardson, Texas 75080
    United States

    Site Not Available

  • Huntsman Cancer Institute/University of Utah

    Salt Lake City, Utah 84112
    United States

    Site Not Available

  • University of Virginia Cancer Center

    Charlottesville, Virginia 22908
    United States

    Site Not Available

  • VCU Massey Cancer Center at Stony Point

    Richmond, Virginia 23235
    United States

    Site Not Available

  • Virginia Commonwealth University/Massey Cancer Center

    Richmond, Virginia 23298
    United States

    Site Not Available

  • Carilion Clinic Gynecological Oncology

    Roanoke, Virginia 24016
    United States

    Active - Recruiting

  • Carilion Roanoke Memorial Hospital

    Roanoke, Virginia 24033
    United States

    Site Not Available

  • Swedish Cancer Institute-Edmonds

    Edmonds, Washington 98026
    United States

    Site Not Available

  • Swedish Cancer Institute-Issaquah

    Issaquah, Washington 98029
    United States

    Site Not Available

  • Swedish Medical Center-First Hill

    Seattle, Washington 98122
    United States

    Site Not Available

  • West Virginia University Charleston Division

    Charleston, West Virginia 25304
    United States

    Site Not Available

  • University of Wisconsin Carbone Cancer Center

    Madison, Wisconsin 53792
    United States

    Active - Recruiting

  • University of Wisconsin Carbone Cancer Center - Eastpark Medical Center

    Madison, Wisconsin 53718
    United States

    Site Not Available

  • University of Wisconsin Carbone Cancer Center - University Hospital

    Madison, Wisconsin 53792
    United States

    Site Not Available

  • Medical College of Wisconsin

    Milwaukee, Wisconsin 53226
    United States

    Site Not Available

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