Precision Medicine for Every Child With Cancer

Last updated: July 16, 2024
Sponsor: Australian & New Zealand Children's Haematology/Oncology Group
Overall Status: Active - Recruiting

Phase

N/A

Condition

Retinoblastoma

Neuroblastoma

Cancer (Pediatric)

Treatment

DNA Methylation

Whole Genome Sequencing

Targeted Panel Sequencing

Clinical Study ID

NCT05504772
ZERO2
  • Ages < 25
  • All Genders

Study Summary

To improve outcomes for childhood cancer patients through the implementation of precision medicine.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. Age < 18 years Note: Individual patients aged 19 - 25 years old with a pediatric cancer, e.g., neuroblastoma, may be enrolled after discussion with, and at the discretion of, the Study Chair or their delegate.

  2. Life expectancy >6 weeks at time of enrolment

  3. Consent i. Signed and dated informed consent for study enrolment from participant aged ≥ 18 years or from parent/guardian of participant aged <18 years. ii. Separate signed and dated informed consent for understanding the role of germline testing and choice for the return of germline results.

Study Design

Total Participants: 3500
Treatment Group(s): 7
Primary Treatment: DNA Methylation
Phase:
Study Start date:
December 16, 2022
Estimated Completion Date:
July 31, 2030

Study Description

Through the pilot TARGET and national PRISM trials the feasibility and benefits of using comprehensive molecular profiling and preclinical drug testing in real time for high-risk (HR) patients has been demonstrated. However, the role of precision medicine, especially in facilitating diagnosis and risk stratification in non-HR childhood cancers has not been studied. Integrative tumor-germline whole genome sequencing (WGS) analysis has the potential to advance our understanding of cancer predisposition. In this study, the ZERO platform will be extended to all children with cancer in Australia and New Zealand, evaluating the benefits of precision medicine in different childhood cancer types and risk groups.

Connect with a study center

  • Women's and Children's Hospital

    Adelaide,
    Australia

    Active - Recruiting

  • Queensland Children's Hospital

    Brisbane,
    Australia

    Active - Recruiting

  • Royal Hobart Hospital

    Hobart,
    Australia

    Active - Recruiting

  • Monash Children's Hospital

    Melbourne,
    Australia

    Active - Recruiting

  • Royal Children's Hospital

    Melbourne,
    Australia

    Active - Recruiting

  • John Hunter Children's Hospital

    Newcastle,
    Australia

    Active - Recruiting

  • Perth Children's Hospital

    Perth,
    Australia

    Active - Recruiting

  • Sydney Children's Hospital, Randwick

    Sydney,
    Australia

    Active - Recruiting

  • The Children's Hospital at Westmead

    Sydney,
    Australia

    Active - Recruiting

  • Starship Children's Hospital

    Auckland, Grafton 1023
    New Zealand

    Active - Recruiting

  • Christchurch Hospital

    Christchurch, 8011
    New Zealand

    Site Not Available

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