Zimberelimab and Domvanalimab in Combination With Chemotherapy Versus Pembrolizumab With Chemotherapy in Patients With Untreated Metastatic Non-Small Cell Lung Cancer

Key Inclusion Criteria:

• Life expectancy ≥ 3 months.

• Pathologically documented NSCLC that meets both of the criteria below:

• Have documented evidence of Stage IV NSCLC disease at the time of enrollment (based on American Joint Committee on Cancer (AJCC), Eighth Edition).

• Have documented negative test results for epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK) mutations.

• Have no actionable genomic alterations such as ROS proto-oncogene 1 (ROS1),neurotrophic tyrosine receptor kinase (NTRK), proto-oncogene B-raf (BRAF), RETmutations, or other driver oncogenes with approved frontline therapies.

• Have not received prior systemic treatment for metastatic NSCLC.

• Measurable disease per RECIST v1.1 criteria by investigator assessment.

• Eastern Cooperative Oncology Group performance status (ECOG PS) score of 0 or 1.

• Have adequate organ functions.

Key Exclusion Criteria:

• Have mixed small-cell lung cancer (SCLC) and NSCLC histology.

• Positive serum pregnancy test or individuals who are breastfeeding or have plans tobreastfeed during the study period.

• Received prior treatment with any anti-PD-1, anti-PD-L1, or any other antibodytargeting an immune checkpoint.

• Known hypersensitivity to the study drug, its metabolites, or formulation excipient.

• Have an active second malignancy or have had an active second malignancy within 3years prior to enrollment.

• Have an active autoimmune disease that required systemic treatment in past 2 years (i.e., with use of disease-modifying agents, corticosteroids, or immunosuppressivedrugs).

• Are receiving chronic systemic steroids.

• Have significant third-space fluid retention.

• Have untreated central nervous system (CNS) metastases and/or carcinomatousmeningitis.

• Active chronic inflammatory bowel disease (ulcerative colitis, Crohn's disease) orgastrointestinal perforation within 6 months of enrollment.

• Has a history of (noninfectious) pneumonitis/interstitial lung disease that requiredsteroids or has current pneumonitis/interstitial lung disease.

• Has had an allogenic tissue/solid organ transplant.

• Have received a live-virus vaccination within 30 days of planned treatment start.Seasonal flu and COVID-19 vaccines that do not contain live virus are permitted.

• Have known active hepatitis B virus (HBV) or hepatitis C virus (HCV) infection.

Note: Other protocol defined Inclusion/Exclusion criteria may apply.