A Study to Test the Effect of TEV-48574 in Moderate to Severe Ulcerative Colitis or Crohn's Disease

Inclusion Criteria:

• Diagnosis of Ulcerative Colitis (UC) or Crohn's Disease (CD) for ≥3 months

• The participant is able to communicate satisfactorily with the investigator and toparticipate in, and comply with, the requirements of the study

• The participant is able to understand the nature of the study and any potentialhazards associated with participating in the study

• Women of non-childbearing potential who are either surgically (documentedhysterectomy, bilateral oophorectomy, or bilateral salpingectomy) or congenitallysterile as assessed by a physician, or 1-year postmenopausal

• Male participants (including vasectomized) with women of childbearing potential (WOCBP) partners (whether pregnant or not) must use condoms after the firstinvestigational medicinal product (IMP) administration and throughout the study oruntil 50 days after the last IMP dose, whichever is longer

NOTE- Additional criteria apply, please contact the investigator for more information

Exclusion Criteria:

• The participant has any concomitant conditions or treatments that could interferewith study conduct, influence the interpretation of study observations/results, orput the participant at increased risk during the study as judged by the investigatorand/or the clinical study physician

• Diagnosis of indeterminate colitis, ischemic colitis, radiation colitis,diverticular disease associated with colitis, or microscopic coliti

• Participant has colonic dysplasia or neoplasia, toxic megacolon, primary sclerosingcholangitis, known non-passable colonic stricture, presence of colonic or smallbowel stoma, presence of non-passable colonic or small bowel obstruction orresection preventing the endoscopy procedure, or fulminant colitis

• Presence of active enteric infections (positive stool culture) or a history ofserious infection (requiring parenteral antibiotic and/or hospitalization) within 4weeks prior to the first screening visit

• Participant anticipates requiring major surgery during this study.

• A participant is Hepatitis B core antibody or surface antigen positive and/orHepatitis C antibody positive with detectable ribonucleic acids, or positive humanimmunodeficiency virus types 1 or 2 at screening.

• A history of an opportunistic infection (eg, cytomegalovirus retinitis, Pneumocystiscarinii, or aspergillosis)

• A history of more than 2 herpes zoster episode in the last 5 years or multimetamericherpes zoster

• A history of or ongoing chronic or recurrent serious infectious disease (eg,infected indwelling prosthesis or osteomyelitis)

• The participant is currently pregnant or lactating or is planning to become pregnantor to lactate during the study or for at least 50 days after administration of thelast dose of IMP in case of early termination. Any woman becoming pregnant duringthe study will be withdrawn from the study.

• Presence of a transplanted organ

• A history of malignancy within the last 5 years (exception: basal cell carcinoma orin situ carcinoma of the cervix if successful curative therapy occurred at least 12months prior to screening) or curatively resected papillary thyroid cance

• Current or history (within 2 years) of serious psychiatric disease or alcohol ordrug abuse

• Participants with incurable diseases, persons in nursing homes, and participantsincapable of giving written informed consent

NOTE- Additional criteria apply, please contact the investigator for more information