Optimization of Deep Brain Stimulation Parameters in Patients With Medically Refractory Epilepsy

Last updated: October 6, 2024
Sponsor: University of Minnesota
Overall Status: Active - Recruiting

Phase

1

Condition

Epilepsy (Pediatric)

Epilepsy

Treatment

PS and OS stimulation order 3

PS and OS stimulation order 1

PS and OS stimulation order 2

Clinical Study ID

NCT05493722
NEUROSURG-2021-29636
  • Ages > 18
  • All Genders

Study Summary

Deep brain stimulation (DBS) is used to treat epilepsy in cases where patients are medically refractory and are not candidates for surgical resection. This therapy has been shown to be effective in seizure reduction, yet very few patients achieve the ultimate goal of seizure freedom. Implantable neural stimulators (INSs) have many parameters that may be adjusted, and could be tuned to achieve very patient specific therapies. This study will develop a platform for stimulation setting optimization based on power spectral density (PSD) measures.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • medically refractory epilepsy

  • already have a deep brain stimulator in place

Exclusion

Exclusion Criteria:

  • severe dementia at investigator discretion

Study Design

Total Participants: 20
Treatment Group(s): 3
Primary Treatment: PS and OS stimulation order 3
Phase: 1
Study Start date:
September 15, 2023
Estimated Completion Date:
January 15, 2030

Connect with a study center

  • University of Minnesota

    Minneapolis, Minnesota 55455
    United States

    Active - Recruiting

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