Non Interventional Safety Study of NUCEIVA for the Treatment of Moderate-to-Severe Glabellar Lines

Inclusion Criteria:

• Patient is an adult less than 65 years of age

• Patient presenting to a participating physician has moderate to severe verticallines between the eyebrows seen at maximum frown (glabellar lines)

• Patient finds their glabellar lines have an important psychological impact

• Written informed consent is obtained from the patient.

Exclusion Criteria:

• Patient has a legal incapacity or limited legal capacity without legal guardianrepresentation

• Patient is currently participating in an interventional study of any investigationalproduct, device or procedure

• Patient has a hypersensitivity to the active substance or to any of the excipientslisted in Section 6.1 of the Summary of Product Characteristics

• Patient has a generalised disorder of muscle activity (e.g. myasthenia gravis orEaton Lambert Syndrome)

• Patient has an infection or inflammation at any of the proposed injection sites

• Patient has a history of dysphagia and/or aspiration

• Female patient is pregnant, is of childbearing potential and not usingcontraception, is breast feeding, or is planning to become pregnant during the next 18 months

• Patient has received prior botulinum toxin for any indication within 3 months ofstudy enrolment.