Deep Brain Stimulation for Refractory Trigeminal Neuralgia with a Pontine Lesion

Last updated: December 6, 2024
Sponsor: Université de Sherbrooke
Overall Status: Active - Recruiting

Phase

1

Condition

Trigeminal Neuralgia

Pain

Pain (Pediatric)

Treatment

Deep brain stimulation

Clinical Study ID

NCT05451251
2025-4672
  • Ages > 18
  • All Genders

Study Summary

The aim of this study is to assess the feasibility of deep brain stimulation for refractory trigeminal neuralgia due to a pontine lesion, as is usually seen in the context of multiple sclerosis.

These patients usually have severe intractable facial pain and current medical and surgical options generally fail to achieve long lasting pain relief.

Hoping to improve pain control in this population, the investigators of this trial propose a novel technique consisting of implanting a deep brain stimulation lead within the pontine lesion to modulate the generation of pain signals.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Adults of at least 18 years old

  • Refractory trigeminal neuralgia : failure of at least 3 drugs and at least twolesioning surgical interventions (radiosurgery, percutaneous rhizotomy, or openrhizotomy).

  • Pontine lesion proved by MRI in contact with trigeminal nerve tract

Exclusion

Exclusion Criteria:

  • Absolute contraindication to MRI

  • Medical contraindication to the procedure

Study Design

Total Participants: 6
Treatment Group(s): 1
Primary Treatment: Deep brain stimulation
Phase: 1
Study Start date:
October 15, 2024
Estimated Completion Date:
October 31, 2026

Connect with a study center

  • Centre Hospitalier Universitaire de Sherbrooke (CHUS)

    Sherbrooke, Quebec J1H 5H3
    Canada

    Active - Recruiting

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