First Live Birth Rate With eSET After Preimplantation Methylome Screening (PIMS) Versus Conventional In-vitro Fertilization

Inclusion Criteria:

1. Women who plan to undergo IVF/ICSI/PGT-A treatment.
2. Women aged 20 years and older. b) Women who obtain 2 or more good-quality blastocysts that defined as morphological scoreof inner cell mass B or A, trophectoderm C or better, and grade 4 or better on Day 5 ofembryo culture.

Exclusion Criteria:

4.2 Exclusion Criteria

1. Women with a uterine cavity abnormality, such as a uterine congenital malformation (uterus unicornate, bicornate, or duplex); untreated uterine septum, submucous myoma,or endometrial polyp(s); or with history of intrauterine adhesions.
2. Women who are indicated and planned to undergo preimplantation genetic testing forstructural rearrangements (PGT-SR) or preimplantation genetic testing for monogenic (PGT-M).
3. Women who use donated oocytes or sperm to achieve pregnancy;
4. Women with contraindication for assisted reproductive technology or for pregnancy,such as poorly controlled Type I or Type II diabetes; undiagnosed liver disease ordysfunction (based on serum liver enzyme testing); renal disease or abnormal serumrenal function; significant anemia; history of deep venous thrombosis, pulmonaryembolus, or cerebrovascular accident; uncontrolled hypertension, known symptomaticheart disease; history of or suspected cervical carcinoma, endometrial carcinoma, orbreast carcinoma; undiagnosed vaginal bleeding.