INSPIRE Trial for Skin and Soft Tissue Infections

Last updated: August 22, 2025
Sponsor: Harvard Pilgrim Health Care
Overall Status: Completed

Phase

N/A

Condition

N/A

Treatment

Arm 2: INSPIRE Stewardship Bundle for Skin and Soft Tissue Infection

Arm 1: Routine Care

Clinical Study ID

NCT05423756
PH000763B_SST
  • Ages > 18
  • All Genders

Study Summary

The INSPIRE Skin and Soft Tissue Infection trial is a cluster-randomized controlled trial of HCA Healthcare hospitals comparing routine empiric antibiotic stewardship practices with real-time, precision medicine computerized physician order entry (CPOE) smart prompts providing the probability that a non-critically ill adult admitted with skin and soft tissue infection is infected with a resistant pathogen.

Note: enrolled "subjects" represent 102 individual HCA Healthcare hospitals that have been randomized into 92 clusters. Hospitals were grouped into the same randomization cluster if they shared campuses or antibiotic stewardship staff.

Eligibility Criteria

Inclusion

Facility Inclusion Criteria:

  1. HCA Healthcare hospitals admitting adults for skin and soft tissue infection

  2. Facility use of MEDITECH as their electronic health record system

Exclusion

Facility Exclusion Criteria:

Note: unit of randomization is the hospital, however the computerized physician order entry (CPOE) alert intervention will calculate risk estimates for adults age >=18 admitted to non-intensive care unit wards and who are ordered to receive extended-spectrum antibiotics for skin and soft tissue infection.

Study Design

Total Participants: 118562
Treatment Group(s): 2
Primary Treatment: Arm 2: INSPIRE Stewardship Bundle for Skin and Soft Tissue Infection
Phase:
Study Start date:
January 01, 2023
Estimated Completion Date:
May 09, 2024

Connect with a study center

  • Riverside Community hospital

    Riverside, California 92501
    United States

    Site Not Available

  • Good Samaritan Hospital

    San Jose, California 95124
    United States

    Site Not Available

  • Regional Medical Center of San Jose

    San Jose, California 95116
    United States

    Site Not Available

  • Los Robles Hospital & Medical Center

    Thousand Oaks, California 91360
    United States

    Site Not Available

  • West Hills Hospital & Medical Center

    West Hills, California 91307
    United States

    Site Not Available

  • Riverside Community hospital

    Riverside 5387877, California 5332921 92501
    United States

    Site Not Available

  • Good Samaritan Hospital

    San Jose 5392171, California 5332921 95124
    United States

    Site Not Available

  • Regional Medical Center of San Jose

    San Jose 5392171, California 5332921 95116
    United States

    Site Not Available

  • Los Robles Hospital & Medical Center

    Thousand Oaks 5402405, California 5332921 91360
    United States

    Site Not Available

  • West Hills Hospital & Medical Center

    West Hills 8030162, California 5332921 91307
    United States

    Site Not Available

  • The Medical Center of Aurora

    Aurora, Colorado 80012
    United States

    Site Not Available

  • Swedish Medical Center

    Englewood, Colorado 80113
    United States

    Site Not Available

  • Sky Ridge Medical Center

    Lone Tree, Colorado 80124
    United States

    Site Not Available

  • North Suburban Medical Center

    Thornton, Colorado 80229
    United States

    Site Not Available

  • The Medical Center of Aurora

    Aurora 5412347, Colorado 5417618 80012
    United States

    Site Not Available

  • Swedish Medical Center

    Englewood 5421250, Colorado 5417618 80113
    United States

    Site Not Available

  • Sky Ridge Medical Center

    Lone Tree 5429208, Colorado 5417618 80124
    United States

    Site Not Available

  • North Suburban Medical Center

    Thornton 5441492, Colorado 5417618 80229
    United States

    Site Not Available

  • Blake Medical Center

    Bradenton, Florida 34209
    United States

    Site Not Available

  • Brandon Regional Hospital

    Brandon, Florida 33511
    United States

    Site Not Available

  • Oak Hill Hospital

    Brooksville, Florida 34613
    United States

    Site Not Available

  • Englewood Community Hospital

    Englewood, Florida 34223
    United States

    Site Not Available

  • Lawnwood Regional Medical Center

    Fort Pierce, Florida 34950
    United States

    Site Not Available

  • Fort Walton Beach Medical Center

    Fort Walton Beach, Florida 32547
    United States

    Site Not Available

  • Regional Medical Center Bayonet Point

    Hudson, Florida 34667
    United States

    Site Not Available

  • Memorial Hospital Jacksonville

    Jacksonville, Florida 32216
    United States

    Site Not Available

  • Lake City Medical Center

    Lake City, Florida 32055
    United States

    Site Not Available

  • Largo Medical Center

    Largo, Florida 33770
    United States

    Site Not Available

  • Northwest Medical Center

    Margate, Florida 33060
    United States

    Site Not Available

  • Kendall Regional Medical Center

    Miami, Florida 33175
    United States

    Site Not Available

  • Mercy Hospital

    Miami, Florida 33133
    United States

    Site Not Available

  • Orange Park Medical Center

    Orange Park, Florida 32073
    United States

    Site Not Available

  • Oviedo Medical Center

    Oviedo, Florida 32765
    United States

    Site Not Available

  • Gulf Coast Regional Medical Center

    Panama City, Florida 32405
    United States

    Site Not Available

  • Fawcett Memorial Hospital

    Port Charlotte, Florida 33952
    United States

    Site Not Available

  • St. Lucie Medical Center

    Port Saint Lucie, Florida 34952
    United States

    Site Not Available

  • Northside Hospital

    Saint Petersburg, Florida 33709
    United States

    Site Not Available

  • Palms of Pasadena

    Saint Petersburg, Florida 33707
    United States

    Site Not Available

  • St. Petersburg General Hospital

    Saint Petersburg, Florida 33710
    United States

    Site Not Available

  • Doctors Hospital of Sarasota

    Sarasota, Florida 34233
    United States

    Site Not Available

  • South Bay Hospital

    Sun City Center, Florida 33573
    United States

    Site Not Available

  • Capital Regional Medical Center

    Tallahassee, Florida 32308
    United States

    Site Not Available

  • HCA Florida South Tampa Hospital

    Tampa, Florida 33609
    United States

    Site Not Available

  • HCA Florida West Tampa Hospital

    Tampa, Florida 33615
    United States

    Site Not Available

  • Medical Center of Trinity

    Trinity, Florida 34655
    United States

    Site Not Available

  • JFK Medical Center - North Campus

    West Palm Beach, Florida 33407
    United States

    Site Not Available

  • Blake Medical Center

    Bradenton 4148708, Florida 4155751 34209
    United States

    Site Not Available

  • Brandon Regional Hospital

    Brandon 4148757, Florida 4155751 33511
    United States

    Site Not Available

  • Oak Hill Hospital

    Brooksville 4148986, Florida 4155751 34613
    United States

    Site Not Available

  • Englewood Community Hospital

    Englewood 4154465, Florida 4155751 34223
    United States

    Site Not Available

  • Fort Walton Beach Medical Center

    Fort Walton Beach 4156042, Florida 4155751 32547
    United States

    Site Not Available

  • Lawnwood Regional Medical Center

    Ft. Pierce 4156018, Florida 4155751 34950
    United States

    Site Not Available

  • Regional Medical Center Bayonet Point

    Hudson 4159335, Florida 4155751 34667
    United States

    Site Not Available

  • Memorial Hospital Jacksonville

    Jacksonville 4160021, Florida 4155751 32216
    United States

    Site Not Available

  • Lake City Medical Center

    Lake City 4161187, Florida 4155751 32055
    United States

    Site Not Available

  • Largo Medical Center

    Largo 4161580, Florida 4155751 33770
    United States

    Site Not Available

  • Northwest Medical Center

    Margate 4163407, Florida 4155751 33060
    United States

    Site Not Available

  • Kendall Regional Medical Center

    Miami 4164138, Florida 4155751 33175
    United States

    Site Not Available

  • Mercy Hospital

    Miami 4164138, Florida 4155751 33133
    United States

    Site Not Available

  • Orange Park Medical Center

    Orange Park 4167102, Florida 4155751 32073
    United States

    Site Not Available

  • Oviedo Medical Center

    Oviedo 4167348, Florida 4155751 32765
    United States

    Site Not Available

  • Gulf Coast Regional Medical Center

    Panama City 4167694, Florida 4155751 32405
    United States

    Site Not Available

  • Fawcett Memorial Hospital

    Port Charlotte 4169130, Florida 4155751 33952
    United States

    Site Not Available

  • St. Lucie Medical Center

    Port Saint Lucie 4169171, Florida 4155751 34952
    United States

    Site Not Available

  • Doctors Hospital of Sarasota

    Sarasota 4172131, Florida 4155751 34233
    United States

    Site Not Available

  • Northside Hospital

    St. Petersburg 4171563, Florida 4155751 33709
    United States

    Site Not Available

  • Palms of Pasadena

    St. Petersburg 4171563, Florida 4155751 33707
    United States

    Site Not Available

  • St. Petersburg General Hospital

    St. Petersburg 4171563, Florida 4155751 33710
    United States

    Site Not Available

  • South Bay Hospital

    Sun City Center 4174317, Florida 4155751 33573
    United States

    Site Not Available

  • Capital Regional Medical Center

    Tallahassee 4174715, Florida 4155751 32308
    United States

    Site Not Available

  • HCA Florida South Tampa Hospital

    Tampa 4174757, Florida 4155751 33609
    United States

    Site Not Available

  • HCA Florida West Tampa Hospital

    Tampa 4174757, Florida 4155751 33615
    United States

    Site Not Available

  • Medical Center of Trinity

    Trinity 4047906, Florida 4155751 34655
    United States

    Site Not Available

  • JFK Medical Center - North Campus

    West Palm Beach 4177887, Florida 4155751 33407
    United States

    Site Not Available

  • Fairview Park Hospital

    Dublin, Georgia 31040
    United States

    Site Not Available

  • Fairview Park Hospital

    Dublin 4192205, Georgia 4197000 31040
    United States

    Site Not Available

  • Eastern Idaho Regional Medical Center

    Idaho Falls, Idaho 83404
    United States

    Site Not Available

  • Eastern Idaho Regional Medical Center

    Idaho Falls 5596475, Idaho 5596512 83404
    United States

    Site Not Available

  • Menorah Medical Center

    Overland Park, Kansas 66209
    United States

    Site Not Available

  • Overland Park Regional Medical Center

    Overland Park, Kansas 66215
    United States

    Site Not Available

  • Wesley Medical Center

    Wichita, Kansas 67214
    United States

    Site Not Available

  • Wesley Woodlawn Hospital & ER

    Wichita, Kansas 67220
    United States

    Site Not Available

  • Menorah Medical Center

    Overland Park 4276873, Kansas 4273857 66209
    United States

    Site Not Available

  • Overland Park Regional Medical Center

    Overland Park 4276873, Kansas 4273857 66215
    United States

    Site Not Available

  • Wesley Medical Center

    Wichita 4281730, Kansas 4273857 67214
    United States

    Site Not Available

  • Wesley Woodlawn Hospital & ER

    Wichita 4281730, Kansas 4273857 67220
    United States

    Site Not Available

  • TriStar Greenview Regional Hospital

    Bowling Green, Kentucky 42104
    United States

    Site Not Available

  • TriStar Greenview Regional Hospital

    Bowling Green 4285268, Kentucky 6254925 42104
    United States

    Site Not Available

  • Lakeview Regional Medical Center

    Covington, Louisiana 70433
    United States

    Site Not Available

  • Tulane Medical Center

    New Orleans, Louisiana 70112
    United States

    Site Not Available

  • Lakeview Regional Medical Center

    Covington 4321005, Louisiana 4331987 70433
    United States

    Site Not Available

  • Tulane Medical Center

    New Orleans 4335045, Louisiana 4331987 70112
    United States

    Site Not Available

  • Centerpoint Medical Center

    Independence, Missouri 64057
    United States

    Site Not Available

  • Research Medical Center

    Kansas City, Missouri 64132
    United States

    Site Not Available

  • Lee's Summit Medical Center

    Lee's Summit, Missouri 64063
    United States

    Site Not Available

  • Centerpoint Medical Center

    Independence 4391812, Missouri 4398678 64057
    United States

    Site Not Available

  • Research Medical Center

    Kansas City 4393217, Missouri 4398678 64132
    United States

    Site Not Available

  • Lee's Summit Medical Center

    Lee's Summit 4394870, Missouri 4398678 64063
    United States

    Site Not Available

  • Southern Hills Hospital & Medical Center

    Las Vegas, Nevada 89148
    United States

    Site Not Available

  • Sunrise Hospital and Medical Center

    Las Vegas, Nevada 89109
    United States

    Site Not Available

  • Southern Hills Hospital & Medical Center

    Las Vegas 5506956, Nevada 5509151 89148
    United States

    Site Not Available

  • Sunrise Hospital and Medical Center

    Las Vegas 5506956, Nevada 5509151 89109
    United States

    Site Not Available

  • Trident Medical Center

    Charleston, South Carolina 29406
    United States

    Site Not Available

  • Grand Strand Medical Center

    Myrtle Beach, South Carolina 29572
    United States

    Site Not Available

  • Trident Medical Center

    Charleston 4574324, South Carolina 4597040 29406
    United States

    Site Not Available

  • Grand Strand Medical Center

    Myrtle Beach 4588718, South Carolina 4597040 29572
    United States

    Site Not Available

  • Parkridge East Hospital

    Chattanooga, Tennessee 37412
    United States

    Site Not Available

  • Parkridge Medical Center

    Chattanooga, Tennessee 37404
    United States

    Site Not Available

  • TriStar Horizon Medical Center

    Dickson, Tennessee 37055
    United States

    Site Not Available

  • TriStar Hendersonville Medical Center

    Hendersonville, Tennessee 37075
    United States

    Site Not Available

  • TriStar Centennial Medical Center

    Nashville, Tennessee 37203
    United States

    Site Not Available

  • TriStar Southern Hills Medical Center

    Nashville, Tennessee 37211
    United States

    Site Not Available

  • TriStar StoneCrest Medical Center

    Smyrna, Tennessee 37167
    United States

    Site Not Available

  • Parkridge East Hospital

    Chattanooga 4612862, Tennessee 4662168 37412
    United States

    Site Not Available

  • Parkridge Medical Center

    Chattanooga 4612862, Tennessee 4662168 37404
    United States

    Site Not Available

  • TriStar Horizon Medical Center

    Dickson 4618057, Tennessee 4662168 37055
    United States

    Site Not Available

  • TriStar Hendersonville Medical Center

    Hendersonville 4628735, Tennessee 4662168 37075
    United States

    Site Not Available

  • TriStar Centennial Medical Center

    Nashville 4644585, Tennessee 4662168 37203
    United States

    Site Not Available

  • TriStar Southern Hills Medical Center

    Nashville 4644585, Tennessee 4662168 37211
    United States

    Site Not Available

  • TriStar StoneCrest Medical Center

    Smyrna 4658590, Tennessee 4662168 37167
    United States

    Site Not Available

  • Medical City Arlington

    Arlington, Texas 76015
    United States

    Site Not Available

  • St. David's Medical Center

    Austin, Texas 78705
    United States

    Site Not Available

  • St. David's North Austin Medical Center

    Austin, Texas 78758
    United States

    Site Not Available

  • Valley Regional Medical Center

    Brownsville, Texas 78526
    United States

    Site Not Available

  • HCA Houston Healthcare Conroe

    Conroe, Texas 77304
    United States

    Site Not Available

  • Corpus Christi Medical Center - Bay Area

    Corpus Christi, Texas 78412
    United States

    Site Not Available

  • Corpus Christi Medical Center - Doctors Regional

    Corpus Christi, Texas 78411
    United States

    Site Not Available

  • Corpus Christi Medical Center - Heart Hospital

    Corpus Christi, Texas 78412
    United States

    Site Not Available

  • Medical City Dallas

    Dallas, Texas 75230
    United States

    Site Not Available

  • Medical City Denton

    Denton, Texas 76210
    United States

    Site Not Available

  • Del Sol Medical Center

    El Paso, Texas 79925
    United States

    Site Not Available

  • Las Palmas Medical Center

    El Paso, Texas 79902
    United States

    Site Not Available

  • Medical City Alliance

    Fort Worth, Texas 76177
    United States

    Site Not Available

  • Medical City Fortworth

    Fort Worth, Texas 76104
    United States

    Site Not Available

  • Medical City Frisco

    Frisco, Texas 75034
    United States

    Site Not Available

  • HCA Houston Healthcare West

    Houston, Texas 77082
    United States

    Site Not Available

  • Medical City Las Colinas

    Irving, Texas 75039
    United States

    Site Not Available

  • HCA Houston Healthcare Kingwood

    Kingwood, Texas 77339
    United States

    Site Not Available

  • Medical City Lewisville

    Lewisville, Texas 75057
    United States

    Site Not Available

  • Methodist Hospital | Metropolitan

    Live Oak, Texas 78212
    United States

    Site Not Available

  • Methodist Hospital | Northeast

    Live Oak, Texas 78233
    United States

    Site Not Available

  • Rio Grande Regional Hospital Main Campus

    McAllen, Texas 78503
    United States

    Site Not Available

  • Medical City McKinney

    McKinney, Texas 75069
    United States

    Site Not Available

  • Medical City North Hills

    North Richland Hills, Texas 76180
    United States

    Site Not Available

  • HCA Houston Healthcare Southeast

    Pasadena, Texas 77504
    United States

    Site Not Available

  • HCA Houston Healthcare Pearland

    Pearland, Texas 77584
    United States

    Site Not Available

  • Medical City Plano

    Plano, Texas 75075
    United States

    Site Not Available

  • St. David's Round Rock Medical Center

    Round Rock, Texas 78681
    United States

    Site Not Available

  • Methodist Hospital

    San Antonio, Texas 78229
    United States

    Site Not Available

  • Methodist Hospital | Specialty and Trasnplant

    San Antonio, Texas 78229
    United States

    Site Not Available

  • Methodist Hospital | Texsan

    San Antonio, Texas 78201
    United States

    Site Not Available

  • HCA Houston Healthcare Mainland

    Texas City, Texas 77591
    United States

    Site Not Available

  • Medical City Weatherford

    Weatherford, Texas 76086
    United States

    Site Not Available

  • HCA Houston Healthcare Clear Lake

    Webster, Texas 77598
    United States

    Site Not Available

  • Medical City Arlington

    Arlington 4671240, Texas 4736286 76015
    United States

    Site Not Available

  • St. David's Medical Center

    Austin 4671654, Texas 4736286 78705
    United States

    Site Not Available

  • St. David's North Austin Medical Center

    Austin 4671654, Texas 4736286 78758
    United States

    Site Not Available

  • Valley Regional Medical Center

    Brownsville 4676740, Texas 4736286 78526
    United States

    Site Not Available

  • HCA Houston Healthcare Conroe

    Conroe 4682991, Texas 4736286 77304
    United States

    Site Not Available

  • Corpus Christi Medical Center - Bay Area

    Corpus Christi 4683416, Texas 4736286 78412
    United States

    Site Not Available

  • Corpus Christi Medical Center - Doctors Regional

    Corpus Christi 4683416, Texas 4736286 78411
    United States

    Site Not Available

  • Corpus Christi Medical Center - Heart Hospital

    Corpus Christi 4683416, Texas 4736286 78412
    United States

    Site Not Available

  • Medical City Dallas

    Dallas 4684888, Texas 4736286 75230
    United States

    Site Not Available

  • Medical City Denton

    Denton 4685907, Texas 4736286 76210
    United States

    Site Not Available

  • Del Sol Medical Center

    El Paso 5520993, Texas 4736286 79925
    United States

    Site Not Available

  • Las Palmas Medical Center

    El Paso 5520993, Texas 4736286 79902
    United States

    Site Not Available

  • Medical City Alliance

    Fort Worth 4691930, Texas 4736286 76177
    United States

    Site Not Available

  • Medical City Fortworth

    Fort Worth 4691930, Texas 4736286 76104
    United States

    Site Not Available

  • Medical City Frisco

    Frisco 4692559, Texas 4736286 75034
    United States

    Site Not Available

  • HCA Houston Healthcare West

    Houston 4699066, Texas 4736286 77082
    United States

    Site Not Available

  • Medical City Las Colinas

    Irving 4700168, Texas 4736286 75039
    United States

    Site Not Available

  • HCA Houston Healthcare Kingwood

    Kingwood 7534469, Texas 4736286 77339
    United States

    Site Not Available

  • Medical City Lewisville

    Lewisville 4706057, Texas 4736286 75057
    United States

    Site Not Available

  • Methodist Hospital | Metropolitan

    Live Oak 4707055, Texas 4736286 78212
    United States

    Site Not Available

  • Methodist Hospital | Northeast

    Live Oak 4707055, Texas 4736286 78233
    United States

    Site Not Available

  • Rio Grande Regional Hospital Main Campus

    McAllen 4709796, Texas 4736286 78503
    United States

    Site Not Available

  • Medical City McKinney

    McKinney 4710178, Texas 4736286 75069
    United States

    Site Not Available

  • Medical City North Hills

    North Richland Hills 4715292, Texas 4736286 76180
    United States

    Site Not Available

  • HCA Houston Healthcare Southeast

    Pasadena 4717782, Texas 4736286 77504
    United States

    Site Not Available

  • HCA Houston Healthcare Pearland

    Pearland 4718097, Texas 4736286 77584
    United States

    Site Not Available

  • Medical City Plano

    Plano 4719457, Texas 4736286 75075
    United States

    Site Not Available

  • St. David's Round Rock Medical Center

    Round Rock 4724129, Texas 4736286 78681
    United States

    Site Not Available

  • Methodist Hospital

    San Antonio 4726206, Texas 4736286 78229
    United States

    Site Not Available

  • Methodist Hospital | Specialty and Trasnplant

    San Antonio 4726206, Texas 4736286 78229
    United States

    Site Not Available

  • Methodist Hospital | Texsan

    San Antonio 4726206, Texas 4736286 78201
    United States

    Site Not Available

  • HCA Houston Healthcare Mainland

    Texas City 4736134, Texas 4736286 77591
    United States

    Site Not Available

  • Medical City Weatherford

    Weatherford 4740364, Texas 4736286 76086
    United States

    Site Not Available

  • HCA Houston Healthcare Clear Lake

    Webster 4740423, Texas 4736286 77598
    United States

    Site Not Available

  • Ogden Regional Medical Center

    Ogden, Utah 84405
    United States

    Site Not Available

  • Ogden Regional Medical Center

    Ogden 5779206, Utah 5549030 84405
    United States

    Site Not Available

  • LewisGale Hospital Montgomery

    Blacksburg, Virginia 24060
    United States

    Site Not Available

  • John Randolph Medical Center

    Hopewell, Virginia 23860
    United States

    Site Not Available

  • LewisGale Hospital Pulaski

    Pulaski, Virginia 24301
    United States

    Site Not Available

  • Reston Hospital Center

    Reston, Virginia 20190
    United States

    Site Not Available

  • CJW Medical Center (Chippenham & Johnston Willis Campuses)

    Richmond, Virginia 23225
    United States

    Site Not Available

  • Henrico Doctor's Hospital

    Richmond, Virginia 23220
    United States

    Site Not Available

  • LewisGale Medical Center

    Salem, Virginia 24153
    United States

    Site Not Available

  • LewisGale Hospital Montgomery

    Blacksburg 4747845, Virginia 6254928 24060
    United States

    Site Not Available

  • John Randolph Medical Center

    Hopewell 4764826, Virginia 6254928 23860
    United States

    Site Not Available

  • LewisGale Hospital Pulaski

    Pulaski 4780577, Virginia 6254928 24301
    United States

    Site Not Available

  • Reston Hospital Center

    Reston 4781530, Virginia 6254928 20190
    United States

    Site Not Available

  • CJW Medical Center (Chippenham & Johnston Willis Campuses)

    Richmond 4781708, Virginia 6254928 23225
    United States

    Site Not Available

  • Henrico Doctor's Hospital

    Richmond 4781708, Virginia 6254928 23220
    United States

    Site Not Available

  • LewisGale Medical Center

    Salem 4784112, Virginia 6254928 24153
    United States

    Site Not Available

Map preview placeholder

Not the study for you?

Let us help you find the best match. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.