COVID-19 Vaccine Uptake Trial

Last updated: April 4, 2025
Sponsor: Washington University School of Medicine
Overall Status: Completed

Phase

N/A

Condition

Covid-19

Treatment

Short Message Service (SMS) + Website Link Strategy

Phone Call with Peer Strategy

Clinical Study ID

NCT05419232
202204166
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

The goal of this study is to assess the best COVID-19 vaccine uptake strategy among students, staff and household members that have not been vaccinated.

There is a multitude of recommendations present that highlight different vaccination strategy; however, it is still unclear which strategy is best to increase COVID-19 vaccination rates. We will compare the effectiveness and acceptance of two different communication strategies among unvaccinated students, staff, and their household members.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. Is not up to date with their COVID-19 vaccinations per CDC guidelines

  2. is considered eligible by the CDC at the time of enrollment to receive a COVID-19vaccine

  3. is a staff, student, or household member of staff or student of one of theparticipating school districts OR a resident of St. Louis City or St. Louis County

Exclusion

Exclusion Criteria:

  1. Is currently up to date with their COVID-19 vaccinations per CDC guidelines

  2. ineligible to receive any COVID-19 vaccine due to medical history or age

  3. is not a staff or student, or household member of staff or student of one of theparticipating school districts AND is not a resident of St. Louis City or St. LouisCounty

  4. participant (or their parents/LAR) do not provide consent.

Study Design

Total Participants: 262
Treatment Group(s): 2
Primary Treatment: Short Message Service (SMS) + Website Link Strategy
Phase:
Study Start date:
July 15, 2022
Estimated Completion Date:
May 31, 2024

Study Description

A sequential multiple assignment randomized trial (SMART) will be conducted to assess two strategies to increase COVID-19 vaccine uptake. The two strategies that will be assessed are a text message with a link to an information website and peer-based motivational interview. If individuals do not seek vaccination after the first intervention, they will again be randomized into the same two interventions. This will allow for testing of both interventions as well as understanding if the use of a more intense intervention (two 'doses') is optimal for vaccine uptake.

In addition, SARS-CoV-2 saliva-based testing will be conducted among students, staff, and household members from the summer of 2022 through the first semester of the 2022-2023 school year. As the pandemic is in its third year, the use of testing among students, staff, and their household members will be assessed Individuals are eligible to be tested multiple times and the testing will occur along different timelines.

Connect with a study center

  • Ferguson-Florissant School District

    Hazelwood, Missouri 63042
    United States

    Site Not Available

  • Jennings School District

    Jennings, Missouri 63136
    United States

    Site Not Available

  • Pattonville School District

    Saint Ann, Missouri 63074
    United States

    Site Not Available

  • Maplewood Richmond Heights School District

    Saint Louis, Missouri 63144
    United States

    Site Not Available

  • Normandy Schools Collaborative

    Saint Louis, Missouri 63121
    United States

    Site Not Available

  • Ritenour School District

    Saint Louis, Missouri 63114
    United States

    Site Not Available

  • St. Louis Language Immersion School

    Saint Louis, Missouri 63103
    United States

    Site Not Available

  • University City School District

    University City, Missouri 63130
    United States

    Site Not Available

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