Neurofeedback for Borderline Personality Disorder

Last updated: November 12, 2024
Sponsor: Kymberly Young
Overall Status: Active - Recruiting

Phase

N/A

Condition

Mood Disorders

Borderline Personality Disorder

Schizotypal Personality Disorder (Spd)

Treatment

Amygdala Neurofeedback

Amygdala Neurofeedback

Clinical Study ID

NCT05398627
STUDY22040107
  • Ages 18-55
  • All Genders

Study Summary

The goal of this study is to evaluate whether rtfMRI-nf training to increase the amygdala response to positive memories may serve as an intervention for borderline personality disorder.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • right-handed adults (ages 18 - 55) with a primary diagnosis of BorderlinePersonality Disorder according to diagnostic criteria in the Structured Interviewfor DSM Personality Disorders

  • must be able to give written informed consent prior to participation

  • unmedicated or stable on an SSRI antidepressant regime (at least 3 weeks to ensuresymptoms are stable)

  • English speaking

Exclusion

Exclusion Criteria:

  • have a clinically significant or unstable cardiovascular, pulmonary, endocrine,neurological, gastrointestinal illness or unstable medical disorder

  • Current moderate or severe DSM-V alcohol or substance use disorder, with theexception of nicotine or caffeine. Clinician will access subjects' alcohol andsubstance use on a case-by-case to determine whether specific cases of mild alcoholor substance use would also interfere with the effects of the intervention.

  • have a history of traumatic brain injury

  • are unable to complete MRI scan due to claustrophobia or general MRI exclusions (e.g., shrapnel inside body)

  • are currently pregnant or breast feeding

  • are unable to complete questionnaires written in English

  • current (within 3 weeks of testing) use of any antipsychotics, benzodiazepines,beta-blockers, or other medications (except SSRI antidepressants) likely toinfluence cerebral blood flow. Effective medications will not be discontinued forthe purposes of the study. Inclusion of patients on stable antidepressantmedications was decided in order to allow generalization towards a real worldpopulation

  • have a DSM-5 diagnosis of psychotic or organic mental disorder

  • have any eye problems or difficulties in corrected vision.

  • Serious suidicial ideation

Study Design

Total Participants: 100
Treatment Group(s): 2
Primary Treatment: Amygdala Neurofeedback
Phase:
Study Start date:
September 02, 2022
Estimated Completion Date:
August 31, 2025

Study Description

We will assess the treatment effects of real-time fMRI neurofeedback in adults with borderline personality disorder. This is an experimental longitudinal design where participants will be followed every two weeks after receiving 2 sessions of neurofeedback from the amygdala . Procedures involve a battery of self-report measures, fMRI and psychophysiological indices (heart rate, respiration).

Connect with a study center

  • University of Pittsburgh

    Pittsburgh, Pennsylvania 15213
    United States

    Active - Recruiting

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