Progressive Resisted Exercise Plus Aerobic Exercise on Osteoporotic Systemic Lupus Erythmatosus

Last updated: September 19, 2024
Sponsor: Cairo University
Overall Status: Completed

Phase

N/A

Condition

Systemic Lupus Erythematosus

Cutaneous Lupus Erythematosus

Musculoskeletal Diseases

Treatment

Progressive resisted exercise training

Aerobic exercises

Calcium and Vit D

Clinical Study ID

NCT05392790
P.T.REC/012/003638
  • Ages 30-50
  • Female

Study Summary

systemic lupus erythematosus (SLE) is the most common autoimmune disease in women of childbearing age. Promoting physical activity is a major national priority for the general population, including patients with chronic diseases. The aim of this study is to investigate the efficiency of combined effect of progressive resisted exercise with aerobic exercise for bone mineral density, quality of life, muscle strength and physical activity for patients with SLE.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Diagnosis of systemic lupus erythematosus by the classification criteria ACRa andthe 2019 EULARb/ACR Classification Criteria for systemic lupus erythematosus

  • Systemic Lupus Erythematosus Disease Activity Index ≥4

  • For 30 day prior, stable immunosuppressive therapy with steroid (0-20 mg/day) orother immunosuppressive medication such as hydroxychloroquine, chloroquine,azathioprine, methotrexate, mycophenolate mofetil, cyclosporine, belimumab,rituximab

Exclusion

Exclusion Criteria:

  • Those who are pregnant.

  • Patients with active lupus nephritis, cardiovascular dysfunction, rhythm andconduction disorders.

  • Patients with musculoskeletal disturbances; kidney and pulmonary involvements;peripheral neuropathy and fibromyalgia.

  • Use of tobacco; treatment with lipid-lowering, chronotropic or antihypertensivedrugs

Study Design

Total Participants: 80
Treatment Group(s): 3
Primary Treatment: Progressive resisted exercise training
Phase:
Study Start date:
May 23, 2022
Estimated Completion Date:
December 30, 2023

Study Description

The following factors were found to be significantly related to lower BMD by univariate analysis: Caucasian race, older age at diagnosis, higher age at the time of the first DXA, longer disease duration, higher cumulative corticosteroid dose, lower serum levels of 25(OH)D, higher SLE Damage Index score, and postmenopausal status. In the multivariate analysis only the following factors were significant: Caucasian race, increased number of pregnancies, postmenopausal status, higher SLE Damage Index, and higher cumulative corticosteroid dose.

As the quality of life among patients with SLE not fully associated with SLE disease activity, pharmacologic treatments that are effective for SLE disease activity might not be able to improve quality of life in these patients Therefore, the benefit of nonpharmacological therapies on quality of life has been explored.

Connect with a study center

  • Nesma Morgan Allam

    Tanta,
    Egypt

    Site Not Available

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