Evaluation of Whole Body Examination by MRI Integrating the "Zero Time Eco" Sequence (ZTE, Pseudo-CT) for the Detection of Bone Lesions in Multiple Myeloma: Comparison With Pet / CT and Whole Body Scanner

Last updated: May 12, 2022
Sponsor: Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Overall Status: Active - Recruiting

Phase

N/A

Condition

Bone Metastases

Lymphoproliferative Disorders

Cancer/tumors

Treatment

N/A

Clinical Study ID

NCT05381077
2020/27JUL/380
  • Ages 18-99
  • All Genders

Study Summary

To assess the added value of magnetic resonance imaging (MRI) of the skeleton compared to other validated techniques for the detection of bone lesions in patients with multiple myeloma.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Patient with newly diagnosed multiple myeloma, for whom bone imaging is required forstaging.
  • Recurrent patient after intensive treatment (high dose chemotherapy, bone marrowtransplant, etc.).
  • Patient requiring a PET / CT considered as the technique of choice in these stages ofthe disease.

Exclusion

Exclusion Criteria:

  • Implanted material incompatible with MRI.
  • Severe claustrophobia.
  • Pregnant women

Study Design

Total Participants: 30
Study Start date:
February 02, 2021
Estimated Completion Date:
August 31, 2023

Study Description

The aim of our study is to offer patients benefiting from a diagnostic approach to myeloma by PET / CT, a whole body MRI examination (MRI-CE) comprising, in addition to the "classic bone marrow" sequences, a ZTE sequence (see below) . This study is being undertaken to compare and assess the complementarity of imaging techniques in the diagnostic management of this disease.

The stages of the work will be:

Optimizing bone marrow exploration sequences by MRI (F. Lecouvet, N. Michoux, Gaetan Duchêne).

Develop and validate a whole body-wide new MRI sequence "ZTE" capable of detecting and quantifying disease-induced osteolysis in the skeleton.

Optimize the reconstruction of these images (Deep Learning software developed with the firm GE), training of the reconstruction of ZTE images by correlation with the scanner (F. Lecouvet, N. Michoux, Gaetan Duchêne).

This approach is completely original, never having been evaluated: the ZTE sequence is a recent development, made available at CUSL on the new research MRI magnet.

The addition of this sequence to the already major information provided by MRI for the detection of the disease and the evaluation of its response (method of choice, see below) would constitute a major advance in establishing the diagnostic value of this technique. non-irradiating compared to other techniques (PET-CT, low dose scanner, etc.).

Connect with a study center

  • Cliniques Universaires Siant Luc

    Brussels, 1200
    Belgium

    Active - Recruiting

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