Pulsed Dye Laser and Intense Pulsed Light Configured With Different Wavelength Bands in Improving Erythematotelangiectatic Rosacea

Last updated: April 30, 2022
Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University
Overall Status: Active - Recruiting

Phase

N/A

Condition

Rosacea

Treatment

N/A

Clinical Study ID

NCT05360251
2022-0177
  • Ages 18-60
  • All Genders

Study Summary

Pulsed dye laser(PDL) and intense pulsed light(IPL) has been widely used in improving rosacea. To compare the efficacy and safety of PDL and IPL configured with different wavelength bands(Delicate Pulsed Light, M22 590, M22 vascular filter) in the treatment of rosacea, we designed a prospective, randomized controlled trial. We hope to make a comparison between PDL and IPL,between broad-spectrum IPL and narrow-spectrum IPL, between single-band IPL and dual-band IPL, and also provide clinical basis for clinicians and patients to develop individualized treatment plans.

Eligibility Criteria

Inclusion

Inclusion Criteria: age of at least 18 years; according to the rosacea diagnostic criteria established by theNRSEC in 2002, be diagnosed as erythematotelangiectatic rosacea; Rosacea clinical score isbetween 9 and 12; Fitzpatrick skin type III and IV;

Exclusion

Exclusion Criteria: there was infection in the treatment site sunburn history within 1 month; received oralisotretinoin or laser treatment in the past 3 months received chemical peeling 1 monthbefore the study pregnancy or breast-feeding. those who are receiving other treatment forrosacea, such as topical and oral drugs;

Study Design

Total Participants: 60
Study Start date:
March 27, 2022
Estimated Completion Date:
July 31, 2022

Study Description

Rosacea is a chronic skin condition characterized by erythema, inflammatory papules, pustules and telangiectasias, which typically occur on the face of middle-aged adults, especially fair skinned. The disease can lead to social stigmatization and may significantly reduce the quality of life of patients. For erythematous lesions and telangiectasia, intense pulsed light (IPL) therapy and lasers are popular treatmen option. Lasers and non-coherent intense pulse light sources (IPL) are based on the principle of selective photothermolysis. The target chromophore in vascular lesions is the oxyhemoglobin present in the red blood corpuscles (RBCs) which circulates in the blood vessels. Pulsed dye lasers (PDL) use a wavelength of 595 nm and is the gold standard of vascular lesion treatment. A common complication is post treatment purpura which appears immediately and can last for 7-14 days, which may be cosmetically unacceptable. The intense pulsed light (IPL) produces a non-coherent light beam with a spectrum of wavelengths from 500 to 1200 nm. Cut-off filters at 515, 550, 570, 590 nm are used for vascular lesions. To compare the efficacy and safety of PDL and IPL configured with different wavelength bands(Delicate Pulsed Light, M22 590, M22 vascular filter) in the treatment of rosacea, we designed a prospective, randomized controlled trial. We hope to make a comparison between PDL and IPL,between broad-spectrum IPL and narrow-spectrum IPL, between single-band IPL and dual-band IPL, and also provide clinical basis for clinicians and patients to develop individualized treatment plans.

Connect with a study center

  • The Second Affiliated Hospital of Zhejiang University of Medicine

    Hanzhou, Zhejiang 0571
    China

    Active - Recruiting

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