High Heated Humidity in Stem Cell Transplant

Inclusion Criteria:

1. Minimum 18 years of age

2. Have given written consent prior to any study-specific procedures or have had anacceptable individual capable of giving consent on the patient's behalf.

3. Have one of non-Hodgkin lymphoma, Hodgkin lymphoma, or multiple myeloma and found torequire high-dose, melphalan-based chemotherapy and autologous stem cell transplant (ASCT) as part of standard of care treatment (includes patients receiving ASCT alsorequiring oxygen).

4. Performance status of ECOG 0-2

5. Are reliable and willing to make themselves available for the duration of the study,and are willing to follow study procedures.

Exclusion Criteria:

1. Nasal blockage such as nasal polyps, deviated septum or nasal packing would eithernot allow the proper flow of heated humidity into the nares or it would be toouncomfortable to tolerate during the intervention.

2. Those with influenza like illness. The intervention is not in itself, an aerosolgenerating medical device. However, if influenza positive, there could be airbornespread of the virus impacting both staff and other patients.

3. Tracheostomy Tube Patients would require a different type of equipment attachmentwhich is not included in this study. Tracheostomy tubes by-pass the upper airway andtherefore the intervention cannot be used for the purpose of assessing mucositis.This intervention is used regularly on tracheostomy patients with good successhowever in this case, the upper airway is by-passed and therefore there would be noimpact on mucositis.

4. Patients with significant co-morbidities that would prevent compliance of equipmentuse as determined by the treating physician.

5. Patients who have Obstructive Sleep Apnea who use a CPAP machine at night. Thispopulation would not be able to use the intervention concurrently with the CPAPdevice as both utilize the nares.