Exploration of Adaptive Antitumoral Immune Cells Through Lymphapheresis in Cancer Patients : ALCYTA

Inclusion Criteria:

1. Patient aged 18 or over,

2. Patient presenting an invasive tumor pathology (proven or suspected). The locationand / or stage of which are defined for each cohort through an amendment to theprotocol,

3. Patient treated with immune-modulators or other treatments likely to modifyimmunological parameters,

4. Suspicion of immune mediated response or toxicities (assessed by the immunologists),

5. Peripheral venous capital usable and compatible with the realization of 2 venousaccesses for lymphapheresis and absence of cardiovascular problem (heart failure,arrhythmia ...), per investigator assessement,

6. Total circulating lymphocytes> 1000 / mm3,

7. Availability of DNA and RNA from the tumor,

8. Information to the patient and signature of informed consent or his legalrepresentative,

9. Affiliated with a social security scheme or such a scheme.

Exclusion Criteria:

1. Inability to undergo study follow-up for geographical, social or psychologicalreasons,

2. Infection with HIV or hepatitis B or C viruses,

3. Patients on high dose corticosteroid treatment (> 1 mg / kg continuously),

4. Any concomitant serious illness that may interfere with participation in the studyor significantly affect the results of the study (pulmonary, heart or liverdisease),

5. Contraindication to performing lymphapheresis (coagulation disorder, cardiovascularproblems, venous access, hypocalcemia, psychological inability to undergoextracorporeal circulation, cachexia, etc.),

6. Pregnant patient or of childbearing age without effective contraception,

7. Persons deprived of their liberty, under guardianship or legal protection.