Phase
Condition
Cardiac Surgery
Anemia
Treatment
conventional treatment
saline
Iron Sucrose, recombinant human erythropoietin, ascorbic acid
Clinical Study ID
Ages > 18 All Genders
Study Summary
Eligibility Criteria
Inclusion
Inclusion Criteria:
Age 18 years and above
Ferritin <300µg/L, transferrin saturation <25%, male 90<Hb<130g/L or female 90<Hb<120g/L
Elective major cardiac surgery (valve replacement, CABG coronary artery bypasssurgery or a combination of both)
ASA: Grade 1-3
Signed informed consent
Exclusion
Exclusion Criteria:
Allergy or contraindication to iron sucrose or recombinant human erythropoietin orascorbic acid
Patients with a preoperative temperature >37.5 °C or on non-prophylactic antibiotics
Pregnancy or breastfeeding stage
weight ≤ 50 kg
Presence of chronic renal insufficiency, urinary stones, oxalate deposits, gout
Chronic liver disease and/or screening alanine transferase/aspartate transferaseabove normal 3 times or more above the upper limit of the normal range
Family history of haemochromatosis, thalassaemia or transferrin saturation > 50%
Known history of iron overload
Other known causes of anaemia (folic acid or vitamin B12 deficiency orhaemoglobinopathies, etc.)
Emergency surgery
Use of iron, blood transfusion or related anaemia treatment within 12 weeks prior tosurgery
Withdrawal criteria:
massive blood transfusion (≥ 10 red blood cells (RBC)/24h)
Preoperative interventions not performed according to standard
Cancellation of surgery
Study Design
Connect with a study center
The Second Affiliated Hospital of Zhejiang University Medical College
Hangzhou, Zhejiang 310000
ChinaActive - Recruiting
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