Clinical Study of Fianlimab in Combination With Cemiplimab Versus Pembrolizumab in Adolescent and Adult Patients With Previously Untreated Unresectable Locally Advanced or Metastatic Melanoma

Last updated: October 28, 2024
Sponsor: Regeneron Pharmaceuticals
Overall Status: Active - Recruiting

Phase

3

Condition

Melanoma

Treatment

Pembrolizumab

Cemiplimab

Fianlimab

Clinical Study ID

NCT05352672
R3767-ONC-2011
2023-505772-30-00
2021-004453-23
  • Ages > 12
  • All Genders

Study Summary

This study is researching an experimental drug called REGN3767, also known as fianlimab (R3767), when combined with another medication called REGN2810, also known as cemiplimab (each individually called a "study drug" or called "study drugs" when combined).

The study is focused on patients with a type of skin cancer known as melanoma. The aims of the study are to see how effective the combination of fianlimab and cemiplimab are in treating the melanoma skin cancer, in comparison with a medication, pembrolizumab, approved for the treatment of melanoma skin cancer in adults, and to observe any similarities, or differences, in how the study drugs work in adolescent participants compared with adult participants.

The study is looking at several other research questions, including:

  • What side effects may happen from receiving the study drugs

  • How much study drug is in the blood at different times

  • Whether the body makes antibodies against the study drugs (which could make the drugs less effective or could lead to side effects). Antibodies are proteins that are naturally found in the blood stream that fight infections.

  • How administering the study drugs might improve quality of life

Eligibility Criteria

Inclusion

Key Inclusion Criteria:

  1. Age ≥12 years on the date of providing informed consent

  2. Patients with histologically confirmed unresectable Stage III and Stage IV (metastatic) melanoma (AJCC, 8th revised edition) who have not received priorsystemic therapy for advanced unresectable disease

  3. Patients who received adjuvant and/or neoadjuvant systemic therapies areeligible if they did not have evidence of progression or recurrence of diseaseand/or discontinued due to occurrence of unmanageable imAEs ≥ grade 3 (with theexclusion of endocrinopathies which are fully controlled by hormonereplacement) while on such therapies. Also, patients must have had atreatment-free and disease-free interval of >6 months. Accrual of thesepatients is limited to approximately 10% of the total population enrolled.

  4. Patients with acral and mucosal melanomas are eligible. Accrual will be limitedto 10% of the total population.

  5. Measurable disease per RECIST v1.1

  6. Previously irradiated lesions can only be counted as target lesions if theyhave been demonstrated to progress and no other target lesion is available

  7. Cutaneous lesions should be evaluated as non-target lesions

  8. Performance status:

  9. For adult patients: Eastern Cooperative Oncology Group (ECOG) performancestatus (PS) 0 or 1

  10. For pediatric patients: Karnofsky performance status ≥70 (patients ≥16 years)or Lansky performance status ≥70 (patients ≤16 years)

  11. Anticipated life expectancy of at least 3 months

Exclusion

Key Exclusion Criteria:

  1. Uveal melanoma

  2. Ongoing or recent (within 2 years) evidence of an autoimmune disease that requiredsystemic treatment with immunosuppressive agents. The following arenon-exclusionary: vitiligo, childhood asthma that has resolved, residualhypothyroidism that requires only hormone replacement, psoriasis not requiringsystemic treatment.

  3. Uncontrolled infection with human immunodeficiency virus (HIV), hepatitis B (HBV) orhepatitis C virus (HCV) infection; or diagnosis of immunodeficiency that is relatedto, or results in chronic infection

  4. Unknown BRAF V600 mutation status as described in the protocol

  5. Systemic immune suppression:

  6. Use of immunosuppressive doses of corticosteroids (>10mg of prednisone per dayor equivalent) within 14 days of the first dose of study medication.Physiologic replacement doses are allowed up to and including 10mg ofprednisone/day or equivalent. Inhaled or topical steroids are permitted, ifthey are not for treatment of an autoimmune disorder.

  7. Other clinically relevant forms of systemic immune suppression

  8. Treatment with other anti-cancer therapy including immuno- therapy, chemotherapy,major surgery or biological therapy within 21 days prior to the first dose of trialtreatment. Adjuvant hormonotherapy used for breast cancer or other hormone-sensitivecancers in long term remission is allowed.

  9. History or current evidence of significant (CTCAE Grade ≥2) local or systemicinfection (e. g., cellulitis, pneumonia, septicemia) requiring systemic antibiotictreatment within 14 days prior to the first dose of trial medication.

  10. Active or untreated brain metastases or spinal cord compression. Patients withleptomeningeal disease are excluded. Patients with known brain metastases areeligible if they:

  11. Received radiotherapy or another appropriate standard therapy for the brainmetastases,

  12. Have neurologically returned to baseline (except for residual signs andsymptoms related to the CNS treatment) for at least 14 days prior to enrollment

  13. Did not require immunosuppressive doses of corticosteroids therapy (>10mg ofprednisone per day or equivalent) in the 14 days prior to enrollment

  14. Are asymptomatic with a single untreated brain metastasis <10 mm in size

  15. Participants with a history of myocarditis.

Note: Other protocol-defined Inclusion/ Exclusion criteria apply

Study Design

Total Participants: 1535
Treatment Group(s): 4
Primary Treatment: Pembrolizumab
Phase: 3
Study Start date:
July 14, 2022
Estimated Completion Date:
June 30, 2031

Connect with a study center

  • The Medical Oncology Centre of Rosebank

    Johannesburg, 02196
    South Africa

    Active - Recruiting

    25.45 miles

  • Groote Schuur Hospital

    Cape Town, 7925
    South Africa

    Active - Recruiting

    806.9 miles

  • Adana Baskent Hospital

    Adana, 01120
    Turkey

    Active - Recruiting

    4,367.56 miles

  • Gaziantep University Medical Faculty

    Gaziantep, 27584
    Turkey

    Active - Recruiting

    4,388.08 miles

  • Hospital Sao Rafael

    Salvador, 41253- 190
    Brazil

    Active - Recruiting

    4,390.99 miles

  • Instituto COI

    Rio de Janeiro, 22793080
    Brazil

    Active - Recruiting

    4,439.55 miles

  • Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto

    Sao Jose do Rio Preto, 15090-000
    Brazil

    Active - Recruiting

    4,439.58 miles

  • Ege University hospital

    Izmir, 35100
    Turkey

    Active - Recruiting

    4,441.44 miles

  • Dicle University Medical Faculty

    Diyarbakir, 21200
    Turkey

    Active - Recruiting

    4,474.52 miles

  • Centro Avancado de Tratamento Oncologico (CENANTRON)

    Belo Horizonte, 30130-090
    Brazil

    Active - Recruiting

    4,552.8 miles

  • Memorial Ankara Hospital

    Ankara, 06520
    Turkey

    Active - Recruiting

    4,555.18 miles

  • Ozel Liv Hospital

    Ankara, 06680
    Turkey

    Active - Recruiting

    4,555.18 miles

  • Gulhane Training and Research Hospital

    Ankara, 06010
    Turkey

    Active - Recruiting

    4,555.18 miles

  • Kocaeli Universitesi

    Kocaeli, 41100
    Turkey

    Active - Recruiting

    4,604.11 miles

  • Bakirkoy Sadi Konuk Training Hospital

    Istanbul, 34147
    Turkey

    Active - Recruiting

    4,620.38 miles

  • Cerrahpasa Medical Hospital

    Istanbul, 34098
    Turkey

    Active - Recruiting

    4,620.38 miles

  • Prof. Dr. Suleyman Yalcin Sehir Hospital

    Istanbul, 34722
    Turkey

    Active - Recruiting

    4,620.38 miles

  • Bezmialem University

    Istanbul, 34093
    Turkey

    Active - Recruiting

    4,620.38 miles

  • Sao Camilo Oncologia

    Sao Paulo, 04014-002
    Brazil

    Active - Recruiting

    4,630.8 miles

  • Hospital Sirio Libanes (HSL)

    Sao Paulo, 01308-050
    Brazil

    Active - Recruiting

    4,630.8 miles

  • Trakya University

    Edirne, 22000
    Turkey

    Active - Recruiting

    4,667.1 miles

  • Clinica de Neoplasias Litoral/atarina Pesquisa Clínica

    Itajai, 88301-220
    Brazil

    Active - Recruiting

    4,675.5 miles

  • Istituto dei Tumori

    Bari, 70124
    Italy

    Active - Recruiting

    4,684.34 miles

  • Fondazione IRCSS Casa Sollievo Della Sofferenza

    San Giovanni Rotondo, 71013
    Italy

    Active - Recruiting

    4,734.97 miles

  • LTD High Technology Hospital Medcenter

    Batumi, 6000
    Georgia

    Active - Recruiting

    4,742.6 miles

  • Liga Paranaense de Combate ao Cancer - Hospital Erasto Gaertner

    Curitiba, 81520-060
    Brazil

    Active - Recruiting

    4,744.1 miles

  • Hospital de Clinicas de Porto Alegre (HCPA)

    Porto Alegre, 90035-903
    Brazil

    Active - Recruiting

    4,754.26 miles

  • CPO - Centro de Pesquisas em Oncologia

    Porto Alegre, 90610-000
    Brazil

    Active - Recruiting

    4,754.26 miles

  • Hospital Moinhos de Vento

    Porto Alegre, 90035-001
    Brazil

    Active - Recruiting

    4,754.26 miles

  • Campus Bio-Medico di Roma

    Rome, 00128
    Italy

    Active - Recruiting

    4,787.2 miles

  • Istituto Dermopatico Dell'Immacolata Irccs

    Rome, 00167
    Italy

    Active - Recruiting

    4,787.2 miles

  • Israeli Georgian medical research clinic Helsicore

    Tbilisi, 0112
    Georgia

    Active - Recruiting

    4,788.38 miles

  • LTD New Hospitals

    Tbilisi, 0114
    Georgia

    Active - Recruiting

    4,788.38 miles

  • LLC Todua Clinic

    Tbilisi, 112
    Georgia

    Active - Recruiting

    4,788.38 miles

  • TIM -Tbilisi Institute of Medicine

    Tbilisi, 0160
    Georgia

    Active - Recruiting

    4,788.38 miles

  • JSC K. Eristavi National Center of Experimental and Clinical Surgery

    Tbilisi, 0159
    Georgia

    Active - Recruiting

    4,788.38 miles

  • LTD Tbilisi State Medical University and Ingorokva High Medical Technology University Clinic

    Tbilisi, 0144
    Georgia

    Active - Recruiting

    4,788.38 miles

  • Medulla - Clinics And Medical Centers

    Tbilisi, 0168
    Georgia

    Active - Recruiting

    4,788.38 miles

  • Hospital Bruno Born

    Lajeado, 95900-000
    Brazil

    Active - Recruiting

    4,808.31 miles

  • Hospital Regional Universitario de Malaga

    Malaga, 29011
    Spain

    Active - Recruiting

    4,815.74 miles

  • Fundacao Pio XII - Hospital de Amor de Barretos

    Barretos, 14784-400
    Brazil

    Active - Recruiting

    4,818.46 miles

  • Hospital Universitario Virgen de las Nieves

    Granada, 18014
    Spain

    Active - Recruiting

    4,819.86 miles

  • Azienda Ospedaliera S. Maria

    Terni, 05100
    Italy

    Active - Recruiting

    4,829.74 miles

  • Centrul de Oncologie Sf. Nectarie S.R.L

    Craiova, 200347
    Romania

    Active - Recruiting

    4,857.33 miles

  • Institute of Oncology Bucharest

    Bucharest, 22328
    Romania

    Active - Recruiting

    4,858.11 miles

  • Hospital Sao Vicente de Paulo (HSVP) Instituto do Cancer

    Passo Fundo, 99010-080
    Brazil

    Active - Recruiting

    4,861.08 miles

  • Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto

    Sao Jose do Rio Preto, 15090-000
    Brazil

    Active - Recruiting

    4,861.3 miles

  • RTC Radiology Therapeutic Center SRL

    Otopeni, 075100
    Romania

    Active - Recruiting

    4,866.28 miles

  • INCLIVA-Instituto de Investigacion Sanitaria

    Valencia, 46010
    Spain

    Active - Recruiting

    4,874.62 miles

  • Instituto Valenciano de Oncologia

    Valencia, 46009
    Spain

    Active - Recruiting

    4,874.62 miles

  • Hospital Universitario Virgen Macarena

    Sevilla, 41009
    Spain

    Active - Recruiting

    4,891.91 miles

  • Hospital Universitario Reina Sofia

    Cordoba, 14004
    Spain

    Active - Recruiting

    4,894.84 miles

  • Catalan Institute of Oncology (ICO) Hospitalet

    Barcelona, 08907
    Spain

    Active - Recruiting

    4,934.91 miles

  • Instituto Oncologico Dr Rosel

    Barcelona, 08028
    Spain

    Active - Recruiting

    4,934.91 miles

  • Hospital de la Santa Creu i Sant Pau

    Barcelona, 08041
    Spain

    Suspended

    4,934.91 miles

  • Hospital Universitari Germans Trias i Pujol (HUGTP)

    Badalona, 08916
    Spain

    Active - Recruiting

    4,936.88 miles

  • U.O. Oncologia Medica Universitaria - Istituto Toscano Tumori Polo Oncologico

    Pisa, 56126
    Italy

    Active - Recruiting

    4,937.37 miles

  • Oncosite Centro De Pesquisa Clinica Em Oncologia

    Ijui, 98700-000
    Brazil

    Active - Recruiting

    4,944.58 miles

  • Catalan Institute Of Oncology - Girona

    Girona, 17007
    Spain

    Active - Recruiting

    4,959.18 miles

  • Oncocenter Oncologie Clinica S.R.L

    Timisoara, 300210
    Romania

    Active - Recruiting

    4,967.27 miles

  • Oncomed

    Timisoara, 300239
    Romania

    Active - Recruiting

    4,967.27 miles

  • University of Szeged

    Szeged, 06720
    Hungary

    Active - Recruiting

    5,007.65 miles

  • University of Pecs Medical School

    Pecs, 7632
    Hungary

    Active - Recruiting

    5,008.56 miles

  • Hospital General Universitario Gregorio Maranon

    Madrid, 28007
    Spain

    Active - Recruiting

    5,016.22 miles

  • Hospital Universitario La Paz

    Madrid, 28046
    Spain

    Active - Recruiting

    5,016.22 miles

  • Hospital Universitario Ramon y Cajal

    Madrid, 28034
    Spain

    Active - Recruiting

    5,016.22 miles

  • Hospital Fundacion Jimenez Diaz

    Madrid, 28040
    Spain

    Active - Recruiting

    5,016.22 miles

  • Centro integral Oncologico HM Clara Campal

    Madrid, 28050
    Spain

    Active - Recruiting

    5,016.22 miles

  • Azienda Sanitaria Ospedaliera Santa Croce E Carle - Cuneo

    Cuneo, 12100
    Italy

    Active - Recruiting

    5,025.15 miles

  • Cardiomed SRL

    Cluj-Napoca, 400015
    Romania

    Active - Recruiting

    5,025.83 miles

  • IOV - Istituto Oncologico Veneto - IRCCS

    Padova, 35128
    Italy

    Active - Recruiting

    5,029.37 miles

  • Fundacion Cenit para la Investigacion en Neurociencias

    Buenos Aires, 1125
    Argentina

    Active - Recruiting

    5,044.96 miles

  • DIABAID - Instituto de Asistencia Integral en Diabetes

    Buenos Aires, C1061
    Argentina

    Active - Recruiting

    5,044.96 miles

  • Regional Institute of Oncology

    Iasi, 700383
    Romania

    Active - Recruiting

    5,045.06 miles

  • SC Centrul de Oncologie Euroclinic SRL

    Iasi, 700106
    Romania

    Active - Recruiting

    5,045.06 miles

  • Azienda Sanitaria Universitaria Friuli Centrale (ASU FC) - Ospedale Udine

    Udine, 33100
    Italy

    Active - Recruiting

    5,056.92 miles

  • ASST Spedali Civili Brescia

    Brescia, 25123
    Italy

    Active - Recruiting

    5,060.42 miles

  • IRCCS Istituto Clinico Humanitas

    Rozzano, 20089
    Italy

    Active - Recruiting

    5,065.62 miles

  • AOU Citta della Salute e della Scienza di Torino

    Turin, 10126
    Italy

    Active - Recruiting

    5,068.48 miles

  • Fondazione IRCCS San Gerardo dei Tintori

    Monza, 20052
    Italy

    Active - Recruiting

    5,076.97 miles

  • SCDU di Oncologia AOU Maggiore Della Carita

    Novara, 28100
    Italy

    Active - Recruiting

    5,078.03 miles

  • Santa Chiara Regional Hospital

    Trento, 38123
    Italy

    Active - Recruiting

    5,083.2 miles

  • University of Debrecen

    Debrecen, 4032
    Hungary

    Active - Recruiting

    5,086.68 miles

  • Medical University of Graz

    Graz, 8036
    Austria

    Active - Recruiting

    5,100.99 miles

  • Centre Hospitalier Universitaire De Grenoble Alpes Service Dermatologie

    Grenoble, 38700
    France

    Active - Recruiting

    5,107.18 miles

  • CHU Saint-Etienne - Hopital Nord

    Saint-Etienne, 42055
    France

    Active - Recruiting

    5,147.87 miles

  • Medical University Of Vienna

    Vienna, 01090
    Austria

    Active - Recruiting

    5,169.37 miles

  • CHU Estaing, Service de Dermatologie

    Clermont-Ferrand, 63003
    France

    Active - Recruiting

    5,194.47 miles

  • Instituto de Oncologia de Rosario

    Rosario, S2000KZE
    Argentina

    Active - Recruiting

    5,206.47 miles

  • Universitatsklinikum Augsburg Klinik fur Dermatologie und Allergologie Campus Sud

    Augsburg, 86179
    Germany

    Active - Recruiting

    5,238.93 miles

  • Hospital Universitario Central de Asturias

    Oviedo, 33011
    Spain

    Active - Recruiting

    5,247.3 miles

  • CHU de DIJON - Service de Dermatologie

    Dijon, 021000
    France

    Active - Recruiting

    5,257.57 miles

  • University Clinic Regensburg

    Regensburg, 93053
    Germany

    Active - Recruiting

    5,267.67 miles

  • Narodowego Instytutu Onkologii im Maria Sklodowska Curie

    Krakow, 31-115
    Poland

    Active - Recruiting

    5,269.58 miles

  • Hospital Universitario Lucus Augusti

    Lugo, 27003
    Spain

    Active - Recruiting

    5,272.71 miles

  • Clinique Sainte Anne/Strasbourg Oncologie Liberale

    Strasbourg, 67000
    France

    Active - Recruiting

    5,296.29 miles

  • Universitätsklinik der Paracelsus Medizinischen Privatuniversität

    Nuremberg, 90419
    Germany

    Active - Recruiting

    5,308.79 miles

  • Hospital Teresa Herrera-Chuac (CHUAC)

    A Coruna, 15009
    Spain

    Active - Recruiting

    5,315.88 miles

  • University Medical Center Mannheim

    Mannheim, 68167
    Germany

    Active - Recruiting

    5,345.22 miles

  • CHU Nantes

    Nantes, 44000
    France

    Active - Recruiting

    5,378.02 miles

  • Centre Hospitalier Universitaire de Nantes (CHU de Nantes) Hotel Dieu

    Nantes, 44000
    France

    Active - Recruiting

    5,378.02 miles

  • Universitatsmedizin der Johanned Gutenberg-Universitat Mainz

    Mainz, 55131
    Germany

    Active - Recruiting

    5,380.52 miles

  • Universitatsklinik Frankfurt

    Frankfurt, 60590
    Germany

    Suspended

    5,383.16 miles

  • Universitaetsklinikum Carl Gustav Carus an der Technischen Universitaet

    Dresden, 01307
    Germany

    Active - Recruiting

    5,386.04 miles

  • CH Le Mans - Plateforme de recherche clinique

    Le Mans, 72037
    France

    Active - Recruiting

    5,390.67 miles

  • Hopitaux Universitaires Henri-Mondor

    Creteil, 94010
    France

    Active - Recruiting

    5,396.74 miles

  • Mazowiecki Szpital Wojewodzki, Siedleckie Centrum Onkologii

    Siedlce, 08-110
    Poland

    Active - Recruiting

    5,402.44 miles

  • Hopital Cochin APHP

    Paris, 75005
    France

    Active - Recruiting

    5,402.91 miles

  • Hopital Avicenne Service de Dermatologie du Pr Caux

    Bobigny, 93000
    France

    Active - Recruiting

    5,404.73 miles

  • Helios Klinikum Erfurt Klinik fur Hautkrankheiten und Allergologie

    Erfurt, 99089
    Germany

    Active - Recruiting

    5,411.03 miles

  • University Hospital Giessen

    Giessen, 35392
    Germany

    Active - Recruiting

    5,414.45 miles

  • Universitaetsklinikum Leipzig

    Leipzig, 4103
    Germany

    Active - Recruiting

    5,419.67 miles

  • Uniwersytecki Szpital Kliniczny w Poznaniu

    Poznan, 60-780
    Poland

    Active - Recruiting

    5,449.97 miles

  • Clinique et Maternite Sainte-Elisabeth (CMSE)

    Namur, 05000
    Belgium

    Active - Recruiting

    5,462.78 miles

  • CHU Charles Nicolle Dermatologie

    Rouen, 76031
    France

    Active - Recruiting

    5,463.21 miles

  • Harzklinikum, Klinik fur Dermatologie und Allergologie

    Quedlinburg, 06484
    Germany

    Active - Recruiting

    5,463.48 miles

  • Charite - Universitaetsmedizin Berlin

    Berlin, 10117
    Germany

    Active - Recruiting

    5,488.16 miles

  • Universitaetsklinikum der Ruhr Universitaet Bochum (UKRUB) St Josef Hospital

    Bochum, 44791
    Germany

    Active - Recruiting

    5,493.32 miles

  • Cliniques Universitaires Saint-Luc

    Brussels, 01200
    Belgium

    Active - Recruiting

    5,495.46 miles

  • AZ Groeninge, Campus Kennedylaan

    Kortrijk, 08500
    Belgium

    Active - Recruiting

    5,512.48 miles

  • Uniwersyteckie Centrum Kliniczne (UCK)

    Gdansk, 80-214
    Poland

    Active - Recruiting

    5,570.46 miles

  • Helios Klinik Schwerin

    Schwerin, 19055
    Germany

    Active - Recruiting

    5,583.15 miles

  • The Netherlands Cancer Institute (NKI) - Antoni van Leeuwenhoek Hospital

    Amsterdam, 1066 CX
    Netherlands

    Active - Recruiting

    5,585.14 miles

  • Wojewodzki Szpital Specjalistyczny im. Janusza Korczaka

    Slupsk, 76-200
    Poland

    Active - Recruiting

    5,589.17 miles

  • Elbekliniken Buxtehude

    Buxtehude, 21614
    Germany

    Active - Recruiting

    5,592.19 miles

  • Royal Surrey NHS Foundation Trust

    Guildford, GU2 7XX
    United Kingdom

    Active - Recruiting

    5,606.51 miles

  • Guy's Hospital

    London, SE1 9RT
    United Kingdom

    Suspended

    5,615.05 miles

  • University Medical Center Groningen

    Groningen, 9713 GZ
    Netherlands

    Active - Recruiting

    5,615.48 miles

  • Centro Medico San Roque

    San Miguel de Tucuman, 4000
    Argentina

    Active - Recruiting

    5,625.54 miles

  • Royal Devon and Exeter Hospital NHS Trust

    Exeter, Devon EX2 5DW
    United Kingdom

    Active - Recruiting

    5,634.08 miles

  • University of Kiel

    Kiel, 24105
    Germany

    Active - Recruiting

    5,643.15 miles

  • Hospital Clinico Universidad de Chile

    Santiago, 8330456
    Chile

    Active - Recruiting

    5,721.98 miles

  • Universidad Mayor - Centro Oncologia de Precision

    Santiago, 7560907
    Chile

    Active - Recruiting

    5,721.98 miles

  • Oncocentro

    Vina del Mar, 2520598
    Chile

    Active - Recruiting

    5,781.31 miles

  • Leeds Teaching Hospitals NHS Trust

    Leeds, LS9 7TF
    United Kingdom

    Active - Recruiting

    5,783.53 miles

  • Cork University Hospital

    Cork, T12 E8YV
    Ireland

    Active - Recruiting

    5,812.43 miles

  • St. James Hospital

    Dublin, D08 NHY1
    Ireland

    Active - Recruiting

    5,849.09 miles

  • University College Hospital Galway

    Galway, H91 YR71
    Ireland

    Active - Recruiting

    5,905.38 miles

  • Centro Oncologico Antofagasta Bradford Hill Norte

    Antofagasta, 1240000
    Chile

    Active - Recruiting

    6,012.43 miles

  • Fundacao PIO XII - Hospital de Amor Amazonia

    Porto Velho, 76834-899
    Brazil

    Active - Recruiting

    6,083.29 miles

  • Calvary North Adelaide Hospital

    Adelaide, 05006
    Australia

    Active - Recruiting

    6,248.49 miles

  • Centro Medico Monte Carmelo

    Arequipa, 04001
    Peru

    Active - Recruiting

    6,307.39 miles

  • Hospital Goyeneche

    Arequipa, 04000
    Peru

    Active - Recruiting

    6,307.39 miles

  • Icon Cancer Centre Hobart

    Hobart, 7000
    Australia

    Active - Recruiting

    6,314.46 miles

  • Barwon Health Andrew Love Cancer Centre, University Hospital Geelong

    Geelong, 03220
    Australia

    Active - Recruiting

    6,387.04 miles

  • The Alfred Hospital

    Melbourne, 03004
    Australia

    Active - Recruiting

    6,427.68 miles

  • Instituto Regional de Enfermedades Neoplasicas del Centro - IREN CENTRO

    Concepcion, 12125
    Peru

    Active - Recruiting

    6,675.99 miles

  • Instituto Peruano de Oncologia and Radioterapia

    Lima, 15036
    Peru

    Suspended

    6,773.77 miles

  • Instituto Nacional de Enfermedades Neoplasicas

    Lima, 2520
    Peru

    Active - Recruiting

    6,773.77 miles

  • Hospital Nacional Daniel Alcides Carrion

    Bellavista, 07001
    Peru

    Active - Recruiting

    6,910.34 miles

  • Clinica Peruano Americana

    Trujillo, 13011
    Peru

    Active - Recruiting

    7,023.56 miles

  • Gold Coast Hospital

    Southport, 4215
    Australia

    Active - Recruiting

    7,233.94 miles

  • Gold Coast University Hospital

    Southport, 4215
    Australia

    Suspended

    7,233.94 miles

  • The Townsville Hospital and Health Service

    Townsville, 04814
    Australia

    Active - Recruiting

    7,272.96 miles

  • Dr. Everett Chalmers Hospital

    Fredericton, E3B5N5
    Canada

    Active - Recruiting

    7,702.09 miles

  • Miami Cancer Institute

    Miami, Florida 33176
    United States

    Active - Recruiting

    8,051.63 miles

  • Orlando Health, Inc

    Orlando, Florida 32806
    United States

    Active - Recruiting

    8,167.13 miles

  • University Health Network, Princess Margaret Cancer Centre

    Toronto, M5G 2M9
    Canada

    Active - Recruiting

    8,280.08 miles

  • Sunnybrook Research Institute

    Toronto, Ontario M4N 3M5
    Canada

    Active - Recruiting

    8,280.08 miles

  • Royal Victoria Regional Health Centre

    Barrie, L4M 6M2
    Canada

    Active - Recruiting

    8,301.18 miles

  • University Hospitals Seidmand Cancer Center

    Cleveland, Ohio 44106
    United States

    Terminated

    8,369.84 miles

  • University of Tennessee Medical Center

    Knoxville, Tennessee 37920
    United States

    Active - Recruiting

    8,426.22 miles

  • Centro De Atencion E Investigacion Clinica En Oncologia Scp

    Merida, 97134
    Mexico

    Active - Recruiting

    8,514.04 miles

  • FAICIC S. de R.L. de C.V.

    Veracruz, 91900
    Mexico

    Active - Recruiting

    8,879.17 miles

  • iCan Oncology Center

    Monterrey, 64710
    Mexico

    Suspended

    9,252.41 miles

  • Antiguo Hospital Civil de Guadalajara Fray Antonio Alcalde

    Guadalajara, 44280
    Mexico

    Active - Recruiting

    9,355.79 miles

  • Investigacion Biomedica para el Desarrollo de Farmacos S.A. de C.V.

    Zapopan, 45070
    Mexico

    Active - Recruiting

    9,359.82 miles

  • Saskatoon Cancer Centre (SCC)

    Saskatoon, S7N 4H4
    Canada

    Active - Recruiting

    9,480.57 miles

  • Centro Estatal de Cancerologia de Chihuahua

    Chihuahua, 31000
    Mexico

    Active - Recruiting

    9,637.72 miles

  • Neurociencias Estudios Clinicos SC

    Culiacan, 80020
    Mexico

    Active - Recruiting

    9,674.6 miles

  • Cross Cancer Institute (CCI)

    Edmonton, T6G-1Z2
    Canada

    Active - Recruiting

    9,699.01 miles

  • University of California San Diego

    La Jolla, California 92093
    United States

    Active - Recruiting

    10,308.43 miles

  • The Angeles Clinic and Research Institute

    Los Angeles, California 90025
    United States

    Active - Recruiting

    10,370.19 miles

  • Medical University Innsbruck

    Innsbruck, Tyrol 6020
    Austria

    Active - Recruiting

  • Instituto Joinvilense De Hematologia E Oncologia

    Joinville, 89201-260
    Brazil

    Active - Recruiting

  • Staedtisches Klinikum Dessau

    Dessau, 06847
    Germany

    Active - Recruiting

  • Hospices Civils de Lyon

    Pierre Benite Cedex, 69495
    France

    Active - Recruiting

  • Institut Gustave Roussy Cancer Center DITEP

    Villejuif Cedex, 94805
    France

    Active - Recruiting

  • Universitatsmedizin Gottingen Klinik fur Dermatologie

    Göttingen, 37075
    Germany

    Active - Recruiting

  • Westfalische Wilhelms Universitaet zu Muenster Fachklinik Hornheide

    Muenster, 48157
    Germany

    Active - Recruiting

  • Klinikum der Universitat Munchen - LMU Klinik und Poliklinik fur Dermatologie und Allergologie Hautt

    Munchen, 80337
    Germany

    Active - Recruiting

  • Istituto di Candiolo, FPO IRCCS

    Candiolo, 10060
    Italy

    Active - Recruiting

  • Preparaciones Oncologicas SC

    Leon, 37178
    Mexico

    Active - Recruiting

  • Cape Town Oncology Trials

    Kraaifontein, 7570
    South Africa

    Active - Recruiting

  • Cleveland Clinic Foundation

    Cleveland, Ohio 44195
    United States

    Active - Recruiting

  • Fakultni nemocnice Kralovske Vinohrady, Dermatovenerologicka klinika

    Prague 10, 10034
    Czechia

    Active - Recruiting

  • CHU Jean MINJOZ

    Besancon Cedex, 25030
    France

    Active - Recruiting

  • Hopital Ambroise Pare

    Boulogne Billancourt, 92100
    France

    Active - Recruiting

  • Chru De Lille

    Lille Cedex, 59037
    France

    Active - Recruiting

  • Istituto Europeo di Oncologia

    Milano, 20141
    Italy

    Active - Recruiting

  • Hull University Teaching Hospitals NHS Trust

    Hull, HU16 5JQ
    United Kingdom

    Active - Recruiting

  • Hemomed

    Sao paulo, 01236-030
    Brazil

    Active - Recruiting

  • Fakultni Nemocnice Hradec Kralove

    Hradec Kralove, 50005
    Czechia

    Active - Recruiting

  • Centre Leon Berard

    Lyon cedex 08, 69373
    France

    Active - Recruiting

  • Universitaetsapotheke Tuebingen

    Tuebingen, 72076
    Germany

    Active - Recruiting

  • Clinica Internacional San Borja

    San Borja, 41
    Peru

    Active - Recruiting

  • Narodowego Instytutu Onkologii im Maria Sklodowska Curie

    Warszawa, 02-781
    Poland

    Active - Recruiting

  • Medisprof

    Cluj Napoca, 400641
    Romania

    Active - Recruiting

  • Hospital Universitario Virgen de la Arrixaca

    Múrcia, 30120
    Spain

    Active - Recruiting

  • Onkologikoa

    San Sebastian, 20014
    Spain

    Active - Recruiting

  • Fundacion CENIT Centro Medico de Neurociencias

    Ciudad Autonoma de Buenos Aires, C1125ABD
    Argentina

    Active - Recruiting

  • University Hospital St. Poelten

    St. Poelten, 3100
    Austria

    Active - Recruiting

  • University Hospital Ostrava

    Ostrava, 70852
    Czechia

    Active - Recruiting

  • Hopital de la Miletrie Centre Hospitalier Universitaire de Poitiers

    Poitiers Cedex, 86021
    France

    Active - Recruiting

  • Ospedale Policlinico San Martino - IRCCS

    Genova, 16132
    Italy

    Active - Recruiting

  • Klinika Nowotworow Tkanek Miekkich, Kosci i Czerniakow

    Warszawa, 02-781
    Poland

    Active - Recruiting

  • Clinica Adventista Belgrano

    Caba, C1430EGF
    Argentina

    Active - Recruiting

  • Ballarat Oncology and Haematology Clinical Trials Unit

    Wendouree, 03355
    Australia

    Active - Recruiting

  • Animi Unidade de Tratamento Oncologico Ltda

    Lages, 88501-001
    Brazil

    Active - Recruiting

  • Bradford Hill

    Recoleta, Chi 8420000
    Chile

    Active - Recruiting

  • Centro De Investigacion Clinica Bradford Hill

    Recoleta, Chi 8420000
    Chile

    Active - Recruiting

  • Oncovida

    Santiago, Region Metropolitana De Santiago 7510032
    Chile

    Active - Recruiting

  • HOPITAL SAINT ANDRE Chu De Bordeaux

    Bordeaux Cedex, 033075
    France

    Active - Recruiting

  • Hopital de la Miletrie Centre Hospitalier Universitaire La Miletrie

    Poitiers Cedex, 86021
    France

    Active - Recruiting

  • Universitaetsklinikum Schleswig-Holstein Campus Luebeck

    Luebeck, 23538
    Germany

    Active - Recruiting

  • Szabolcs-Szatmar-Bereg Megyei Korhazak es Egyetemi Oktato Korhazak

    Nyíregyhaza, 04400
    Hungary

    Active - Recruiting

  • St. Vincents University Hospital

    Dublin 4, D04 T6F4
    Ireland

    Active - Recruiting

  • IRCCS Istituto Nazionale dei Tumori di Napoli Fondazione G. Pascale

    Napoli, 80131
    Italy

    Active - Recruiting

  • Università della Campania Luigi Vanvitella

    Napoli, 80121
    Italy

    Active - Recruiting

  • SC Radiotherapy Center Cluj SRL

    Cluj, 407280
    Romania

    Active - Recruiting

  • Atlantic Health System - Morristown Medical Center

    Morristown, New Jersey 07962
    United States

    Active - Recruiting

  • AZ Nikolaas

    Sint Niklaas, 09100
    Belgium

    Active - Recruiting

  • INCA - Brazilian National Cancer Institute

    Santo Cristo, 20220-410
    Brazil

    Active - Recruiting

  • Fachklinik Hornheide

    Muenster, 48157
    Germany

    Active - Recruiting

  • Istituti Fisioterapici Ospitalieri (IFO)

    Roma, 00144
    Italy

    Active - Recruiting

  • Centro De Estudios Y Prevencion Del Cancer A. C.

    Tuxtla Gutierrez, 290838
    Mexico

    Active - Recruiting

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