Novel Targeted Drugs Combined With R-ICE Regimen in Relapsed and Refractory Diffuse Large B-cell Lymphoma

Inclusion Criteria:

• DLBCL was confirmed by histology according to world Health Organization (WHO)disease classification (excluding primary central lymphoma and HIV-associatedlymphoma);

• There are evaluable lesions detected by PET/CT;

• Life expectancy of more than 3 months;

• Prior treatment with sufficient first-line anti-lymphoma therapy, no remissionwithin 90 days of the last administration, or disease progression after sufficientfirst-line anti-lymphoma therapy, and no current anti-lymphoma therapy (≥2 weekssince the last anti-lymphoma therapy). Patients were allowed to receive hormonedrugs or rituximab at least 1 week after enrollment for symptom control reasons;

• 18≤ age ≤75 years old, male and female;

• ECOG 0-2 points;

• No serious organic lesions in the main organs, meeting the requirements of thefollowing laboratory examination indicators (conducted within 7 days beforetreatment) :

① Absolute value of neutrophil count ≥1500/mm3; Platelet count ≥75,000/mm3

② Total bilirubin ≤2× upper limit of normal value (ULN)

③ Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) (serumglutamate pyruvate aminotransferase [SGPT]) ≤3× upper limit of normal value (ULN)

④ the creatinine clearance rate was ≥60ml/min

⑤ No cardiac dysfunction

• If the subject is of reproductive age and requires effective contraception, he/sheagrees to comply with all contraceptive requirements: 1) there are fertile womenhave to decide, at the same time take two reliable contraceptive methods (a kind ofhigh efficient contraceptives - tubal ligation, intrauterine contraceptive device,hormone (birth control pills, needle, patch, vaginal ring or implants) or partnervasectomy, another effective birth control method -- men or synthetic rubber condom,diaphragm or cervical cap). 2) Unless hysterectomy, effective contraception isrequired even if there is a history of infertility;

• Fertile men must always use rubber or synthetic condoms when having sexual contactwith fertile women during the use of this product and within 28 days ofdiscontinuation of this product, even if they have successfully vasectomy; Thesubjects knew the characteristics of the disease, voluntarily joined the study,received treatment and follow-up, and the informed consent was signed by thesubjects themselves or their guardians and impartial witnesses.

Exclusion Criteria:

• Pregnant or lactating women (lactating women must agree not to breastfeed whiletaking pomadomide);

• Known hepatitis B (HBV), hepatitis C (HCV) infection (HBV infection refers toHBV-DNA > detectable limit); And other acquired, congenital immune deficiencydisorders, including but not limited to HIV-infected persons;

• Subjects with a history of deep vein thrombosis (DVT) or pulmonary embolism (PE)within the past 12 months;

• Bone marrow failure, defined as ANC<1500/mm3 or platelet <75,000/mm3, unlesshematologic changes are thought to be associated with lymphomas infiltrating thebone marrow;

• Clinically significant heart disease, including unstable angina, acute myocardialinfarction 6 months before enrollment, congestive heart failure (NYHA) heartfunction grade III or IV; Or left ventricular ejection fraction <50%;

• Lymphoma with central nervous system (CNS) involvement;

• Those who are known to be allergic to the test drug ingredients;

• Those who have received grade II or above surgery within three weeks beforetreatment;

• Patients who have received organ transplants;

• Has been diagnosed with or is being treated for malignancy other than lymphoma,except for:

① They have received therapeutic treatment and have not had known active diseasemalignancy for ≥5 years prior to enrollment;

② Basal cell carcinoma of the skin (except melanoma) without signs of disease afteradequate treatment;

③ Cervical carcinoma in situ without signs of disease after adequate treatment.

• With severe infection;

• Substance abuse, medical, psychological, or social conditions that may interferewith the subjects' participation in the study or evaluation of the study results;The researchers deemed unsuitable for the group.