Examining the Benefit of Graduated Compression Stockings in the Prevention of vEnous Thromboembolism in Low-risk Surgical Patients

Last updated: March 27, 2024
Sponsor: Imperial College London
Overall Status: Active - Recruiting

Phase

N/A

Condition

Blood Clots

Thromboembolism

Venous Thromboembolism

Treatment

Graduated Compression Stockings - Thromboembolic deterrent stockings

Clinical Study ID

NCT05347550
22CX7651
  • Ages 18-59
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

Hospital acquired thrombosis describes blood clots that form in the legs and lungs after someone is treated in hospital. Clots in the leg can cause swelling, pain and other problems. If a clot in the leg travels to the lungs, it may be life threatening. Having surgery increases the risk of developing blood clots.

People having short-stay surgery (who either go home the same day or who stay overnight but go home shortly afterwards) are at a much lower risk of developing a blood clot than those who stay in hospital for longer. These low-risk people are often given elastic stockings (which squeeze the leg muscles) to reduce the chance of a blood clot.

The risks of wearing the stockings are low but they can be uncomfortable. In the UK, there are over a million short stay surgeries performed each year and most of these people are given elastic stockings to wear. Stockings cost the NHS a lot of money and it remains unknown if they work.

This study will investigate if it is worthwhile to continue using elastic stockings in people having surgery where the risk of developing blood clots is low. Adults (over 18-years) who are at low risk of developing blood clots (assessed using a nationally recognised tool) will be included.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Adults (18-59 years of age) scheduled to undergo a surgical procedure with a hospitalstay <48 hours
  • Individuals assessed as being at low-risk of developing VTE as per the DHRA Tool (i.e.no assessed thrombosis risk factors / scoring 0)

Exclusion

Exclusion Criteria:

  • Individuals with a contraindication to GCS
  • Individuals assessed as being at moderate or high-risk of VTE as per the DHRA tool
  • Individuals requiring therapeutic anticoagulation
  • Individuals with thrombophilia/ thrombogenic disorder
  • Individuals with a previous history of VTE
  • Individuals requiring intermittent pneumatic compression therapy beyond theatre andrecovery
  • Individuals requiring extended thromboprophylaxis beyond discharge
  • Female patients of childbearing age who have a positive pregnancy test
  • Individuals with lower limb immobilisation
  • Inability to provide informed consent

Study Design

Total Participants: 21472
Treatment Group(s): 1
Primary Treatment: Graduated Compression Stockings - Thromboembolic deterrent stockings
Phase:
Study Start date:
September 08, 2022
Estimated Completion Date:
December 31, 2025

Connect with a study center

  • Barnsley Hospital NHS Foundation Trust

    Barnsley,
    United Kingdom

    Active - Recruiting

  • Frimley Health NHS Foundation Trust

    Camberley,
    United Kingdom

    Active - Recruiting

  • Queen Victoria Hospital NHS Foundation Trust

    East Grinstead,
    United Kingdom

    Active - Recruiting

  • Imperial College Hospital NHS Foundation Trust

    London,
    United Kingdom

    Active - Recruiting

  • South Tees Hospitals NHS Foundation Trust

    Middlesbrough,
    United Kingdom

    Active - Recruiting

  • The Newcastle upon Tyne Hospitals NHS Foundation Trust

    Newcastle Upon Tyne,
    United Kingdom

    Active - Recruiting

  • Sherwood Forest Hospital NHS Foundation Trust

    Nottingham,
    United Kingdom

    Active - Recruiting

  • North Tees and Hartlepool NHS Foundation Trust

    Stockton-on-Tees,
    United Kingdom

    Active - Recruiting

  • Somerset NHS Foundation Trust

    Taunton,
    United Kingdom

    Active - Recruiting

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