Atrial Fibrillation Patients Treated With Catheter Ablation

Last updated: June 4, 2025
Sponsor: Peking Union Medical College Hospital
Overall Status: Active - Recruiting

Phase

N/A

Condition

Dysrhythmia

Chest Pain

Cardiac Disease

Treatment

radiofrequency ablation

Clinical Study ID

NCT05266144
PUMCH-AF
  • Ages 18-80
  • All Genders

Study Summary

This is a single-center prospective observational cohort study of atrial fibrillation patients treated with radiofrequency ablation.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Non-valvular atrial fibrillation, including paroxysmal atrial fibrillation andpersistent atrial fibrillation

  • 18-80 years old

  • The anteroposterior diameter of the left atrium is less than 50mm via TTE

  • Patient meets the intervention criteria for bilateral pulmonary vein isolation afterevaluation by electrophysiological specialists

  • Patient consents to ablation treatment

Exclusion

Exclusion Criteria:

  • Intra-atrial thrombus detected by TEE

  • Hyperthyroidism

  • Previous radiofrequency ablation for atrial fibrillation

Study Design

Total Participants: 300
Treatment Group(s): 1
Primary Treatment: radiofrequency ablation
Phase:
Study Start date:
September 04, 2020
Estimated Completion Date:
December 31, 2025

Study Description

The effect of radiofrequency therapy on the life quality and atrial function of atrial fibrillation patients will be assessed, through the multidimensional analysis of baseline clinical data, serological indicators of atrial fibrosis, echocardiography, cardiac magnetic resonance imaging, atrial potential mapping, life quality, and long-term ECG monitoring within 1 week after radiofrequency ablation. A predictive model for atrial fibrillation recurrence after ablation will be established. Based on the cross-sectional analysis of baseline data, the relationship between non-invasive assessment of atrial fibrosis (imaging and serology), atrial electrical activity, and atrial function will be analyzed as well, and atrial fibrillation patients with ventricular fibrosis will be selected for gene sequencing to explore the existence of underlying cardiomyopathy and provide data for further research.

Connect with a study center

  • Peking Union Medical College Hospital

    Beijing, Beijing 100005
    China

    Active - Recruiting

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