Autologous Dendritic Cells and Allogenic Dendritic Secretomes for Patients With Advanced Nasopharyngeal Cancer

Last updated: February 23, 2026
Sponsor: PT. Prodia Stem Cell Indonesia
Overall Status: Active - Not Recruiting

Phase

1/2

Condition

Nasopharyngeal Cancer

Treatment

Combination of Auto DC and Allo-Dendritic Cell-Secretome (Allogeneic Dendritic Cell-Secretome as Adjuvant Therapy)

Auto-DC (Autologous Dendritic Cell as Adjuvant Therapy)

Placebo (Aqua Pro-Injection)

Clinical Study ID

NCT05261750
CT/NPC/PSI/2022
  • Ages 18-80
  • All Genders

Study Summary

The purpose of this study is to determine the safety and potential of dendritic cells therapy and secretomes therapy for advanced nasopharyngeal cancer.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Patients who tested positive EBV and confirmed suffering advanced nasopharyngealcancer

  • Patients who have partial response or stable disease or progressive disease afterperformed standard therapy (radiology or chemoradiation) based on RECIST

  • Did not take traditional medicine in the last 2 months.

  • Patients can understand the nature of the study and willing to sign informed consent

  • Patients who received standard medical (radiology or chemoradiation) up to oneadditional therapy in the last 1 month.

Exclusion

Exclusion Criteria:

  • Patients who are pregnant, planning to pregnant, or breastfeeding

  • Patients assessed to require chemoradiation during this study

  • Patients who get complete score after undergo standard therapy (radiology orchemoradiation) based on the RECIST

  • Patients who have autoimun reaction, eczema, allergy or allergy history, andanaphylaxis

  • Patients who have creatinin clearance result <40 ml/min, bilirubin serum >1.5x abovenormal, SGPT-SGOT >5x above normal

  • Patients on immunosuppressive medications, such as corticosteroids

  • Patients who undergo Major thoracic or abdominal operation

  • Patients on high medical risk condition due to uncontrolled infection

  • Patients who diagnosed positive of Hepatitis B, Hepatitis C or HumanImmunodeificiency virus (HIV)

  • Patients who have concurrent congestive heart failure history and other heartdisease

  • Patients who have health conditions assessed by the doctor in charge cannot beincluded in this clinical trial

  • Patients who refuse or did not participate in part or all of the research process

Study Design

Total Participants: 15
Treatment Group(s): 3
Primary Treatment: Combination of Auto DC and Allo-Dendritic Cell-Secretome (Allogeneic Dendritic Cell-Secretome as Adjuvant Therapy)
Phase: 1/2
Study Start date:
April 30, 2022
Estimated Completion Date:
February 28, 2026

Study Description

There are three arms controlled group. First group receives standard medical theraphy (radiotherapy or chemoradiation), second group who receives autologous dendritic cell (Auto-DC), and third group receives the combination of allogenic-dendritic cell-secretomes (Allo-DC Secretome) and continued with autologous dendritic cell (Auto-DC).

Connect with a study center

  • PT Prodia StemCell Indonesia

    Jakarta,
    Indonesia

    Site Not Available

  • PT Prodia StemCell Indonesia

    Jakarta 1642911,
    Indonesia

    Site Not Available

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