Motivational Interviewing to Address Suicidal Ideation for Veterans at High Risk for Suicide

Last updated: January 15, 2025
Sponsor: VA Office of Research and Development
Overall Status: Active - Recruiting

Phase

N/A

Condition

Suicide

Treatment

Enhanced usual care (EUC)

Motivational Interviewing to Address Suicidal Ideation- Revised (MI-SI-R)

Clinical Study ID

NCT05256940
MHBC-001-21S
I01CX002359
  • Ages > 18
  • All Genders

Study Summary

The purpose of this project is to conduct a randomized control trial with 470 Veterans to examine the impact of a revised version of Motivational Interviewing to Address Suicidal Ideation (MI-SI-R) on risk for suicide attempts and suicidal ideation when compared to high quality usual care.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Veteran status,

  • admitted to an inpatient unit, referred by a suicide prevention coordinator, oridentified as high-risk via data extraction,

  • age 18 and over,

  • English speaking and reading, and

  • ability to understand the study and provide informed consent,

  • high-risk status confirmed by suicide attempt within a month on the Columbia-Suicide Severity Rating Scale or a score > 5 on the Scale for Suicidal Ideation

Exclusion

Exclusion Criteria:

  • current psychosis,

  • active mania,

  • dementia,

  • impaired decision making capacity, and

  • institutionalization due to hospitalization in a non-VA facility, jail, or prison.

Study Design

Total Participants: 470
Treatment Group(s): 2
Primary Treatment: Enhanced usual care (EUC)
Phase:
Study Start date:
November 30, 2022
Estimated Completion Date:
June 29, 2027

Study Description

Research suggests that treatments to reduce suicidal behavior may need to focus on both the motivation to live and the motivation to die to obtain optimal effects. The PI developed a revised version of Motivational Interviewing to Address Suicidal Ideation (MI-SI-R) to help Veterans resolve ambivalence about living by increasing the motivation to live, that consists of three sessions delivered in-person, virtually, or by telephone. Enhanced usual care (EUC) for high-risk Veterans includes safety plans administered or reviewed by research therapists, care coordination, and access to a 24-hour crisis hotline. In a preliminary randomized controlled trial (RCT) in psychiatrically hospitalized Veterans, MI-SI-R plus EUC was associated with 50% fewer suicide attempts and 41% lower likelihood of suicidal ideation compared to EUC alone. The investigators are proposing an RCT comparing MI-SI-R plus EUC (MI-SI-R+EUC) to EUC alone in a sample of 470 high-risk Veterans with recent suicidal crises from three VHA Medical Centers, with "high-risk" defined as a suicide attempt within a month or suicidal ideation > 5 on the Beck Scale for Suicidal Ideation. Half (n = 235) will be randomized to MI-SI-R+EUC (three sessions in-person, via Video Connect, or telephone) and the remaining participants (n = 235) will receive EUC alone. All participants will be asked to complete telephone follow-up assessments at 1, 3, 6, and 12-months after randomization. This will allow the investigators to determine the efficacy of MI-SI-R+EUC in reducing risk for suicide attempts (Aim 1) and reducing overall suicidal ideation (Aim 2) when compared to EUC alone.

Connect with a study center

  • Canandaigua VA Medical Center, Canandaigua, NY

    Canandaigua, New York 14424
    United States

    Active - Recruiting

  • VA Finger Lakes Healthcare System, Canandaigua, NY

    Canandaigua, New York 14424-1159
    United States

    Active - Recruiting

  • VA Portland Health Care System, Portland, OR

    Portland, Oregon 97207-2964
    United States

    Active - Recruiting

  • Ralph H. Johnson VA Medical Center, Charleston, SC

    Charleston, South Carolina 29401-5703
    United States

    Active - Recruiting

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