Phase
Condition
Lymphoma
Treatment
Nivolumab
Relatlimab
Clinical Study ID
Ages < 30 All Genders
Study Summary
Eligibility Criteria
Inclusion
Inclusion Criteria:
Participants with pathologically confirmed high-risk R/R cHL, after non-response toor failure of 1or more lines of standard therapy.
Participants with pathologically confirmed R/R NHL after non-response to or failureof 1or more lines of standard therapy, including, but not limited to, R/R primarymediastinal B-cell lymphoma, diffuse large B-cell lymphoma (DLBCL), mediastinal grayzone lymphoma (MGZL), anaplastic large cell lymphoma (ALCL), or peripheral T-celllymphoma (PTCL).
Participants with pathologically confirmed R/R NHL after non-response to or failureof 2 or more lines of standard therapy, including Burkitt lymphoma (blast count <25%malignant Burkitt cells and/or per the investigator's clinical assessment of riskstatus), lymphoblastic lymphoma (blast count < 25% of marrow nucleated cells and/orper the investigator's clinical assessment of risk status), NK/T-cell lymphoma (nasal and non-nasal NK/T-cell lymphoma subtypes, but not aggressive NK/T-cellleukemia/lymphoma subtype).
The participant's current disease state must be R/R to standard therapy.
Participants must have measurable PET positive disease in both cHL and NHL cohorts.
Exclusion
Exclusion Criteria:
Primary CNS lymphoma of the brain or spinal cord, and secondary CNS lymphoma (ie,from systemic non-Hodgkin lymphoma) involving the brain, spinal cord, or withleptomeningeal seeding.
Prior treatment with an anti-cytotoxic T-lymphocyte-associated protein 4 (anti-CTLA-4) antibody, or any other antibody or drug specifically targeting T-cellco-stimulation or checkpoint pathways, with the exception of anti-PD(L)-1 targetedtherapies.
Prior treatment with lymphocyte activation gene-3 (LAG-3)-targeted agents.
Participants with clinically significant systemic illnesses unrelated to the canceras judged by the investigators, which would compromise the participant's ability totolerate the study treatment.
Participants with autoimmune disease.
Prior allogeneic bone marrow transplantation.
Other protocol-defined inclusion/exclusion criteria apply
Study Design
Connect with a study center
Local Institution - 0037
Randwick, New South Wales 2031
AustraliaActive - Recruiting
University of New South Wales UNSW - Sydney Childrens Hospital SCH - The Centre for Cancer and Blood Disorders
Randwick, New South Wales 2031
AustraliaActive - Recruiting
Local Institution - 0039
South Brisbane, Queensland 4101
AustraliaActive - Recruiting
Local Institution
Nedlands, Western Australia 6009
AustraliaSite Not Available
Local Institution - 0042
Nedlands, Western Australia 6009
AustraliaSite Not Available
Perth Childrens Hospital
Nedlands, Western Australia 6009
AustraliaActive - Recruiting
Perth Childrens Hospital
Perth, Western Australia 6009
AustraliaSite Not Available
Local Institution - 0063
Angers, Angers Cedex 9 49933
FranceActive - Recruiting
Groupe Hospitalier Pellegrin - Hopital des enfants
Bordeaux, 33076
FranceActive - Recruiting
Local Institution - 0048
Bordeaux, 33076
FranceActive - Recruiting
Local Institution - 0033
Caen, 14033
FranceSite Not Available
CHU Grenoble Alpes - Hopital Couple Enfant (HCE)
La Tronche, 38700
FranceActive - Recruiting
Local Institution - 0067
La Tronche, 38700
FranceSite Not Available
Institut d Hematologie et d Oncologie Pediatriques
Lyon, 69373 Cedex 08
FranceActive - Recruiting
Local Institution - 0021
Lyon, 69373 Cedex 08
FranceActive - Recruiting
Local Institution - 0034
Marseille, 13385
FranceSite Not Available
Local Institution - 0018
Montpellier, 34295
FranceActive - Recruiting
Local Institution - 0021
Nimes, 30029
FranceSite Not Available
Assistance Publique-Hopitaux de Paris AP-HP - Hopital Universitaire Robert-Debre
Paris, 75935
FranceActive - Recruiting
Local Institution - 0006
Paris, 75571
FranceActive - Recruiting
Local Institution - 0047
Paris, 75935
FranceSite Not Available
Local Institution - 0022
Rennes, 35203
FranceSite Not Available
CHRU de Strasbourg-Hopital de Hautepierre
Strasbourg, 67000
FranceActive - Recruiting
Local Institution - 0052
Strasbourg, 67000
FranceSite Not Available
Local Institution
Aachen, 52074
GermanySite Not Available
Local Institution - 0056
Aachen, 52074
GermanySite Not Available
Local Institution
Berlin, 13353
GermanySite Not Available
Local Institution - 0015
Berlin, 13353
GermanySite Not Available
Local Institution
Giessen, 35392
GermanySite Not Available
Local Institution - 0028
Giessen, 35392
GermanySite Not Available
Local Institution - 0036
Hamburg, 20246
GermanySite Not Available
Local Institution
Muenster, 48149
GermanySite Not Available
Local Institution - 0008
Muenster, 48149
GermanySite Not Available
Local Institution
Munich, 80337
GermanySite Not Available
Local Institution - 0051
Munich, 80337
GermanySite Not Available
Local Institution - 0041
Pavia, PV 27100
ItalySite Not Available
Local Institution - 0010
Aviano, 33081
ItalySite Not Available
Local Institution - 0007
Bologna, 40138
ItalyActive - Recruiting
Azienda Ospedaliero Universitaria Meyer
Florence, 50139
ItalyActive - Recruiting
Local Institution - 0040
Florence, 50139
ItalyActive - Recruiting
Local Institution - 0005
Genoa, 16147
ItalySite Not Available
Local Institution - 0070
Milan, 20162
ItalySite Not Available
Local Institution
Milano,
ItalySite Not Available
Local Institution - 0001
Milano, 20133
ItalyActive - Recruiting
Local Institution - 0043
Monza, 20900
ItalyActive - Recruiting
Local Institution - 0013
Napoli, 80131
ItalySite Not Available
Azienda Ospedale Universita Padova
Padova, 35128
ItalyActive - Recruiting
Local Institution - 0065
Padova, 35128
ItalySite Not Available
Local Institution - 0002
Roma, 0165
ItalySite Not Available
Osp. Pediatrico Bambino Gesu, IRCCS
Roma, 00165
ItalyActive - Recruiting
Local Institution - 0004
Turin, 10126
ItalyActive - Recruiting
Local Institution - 0057
Utrecht, 3584 CS
NetherlandsActive - Recruiting
Princess Maxima Center for pediatric oncology
Utrecht, 3584 CS
NetherlandsActive - Recruiting
Clinica Universidad de Navarra
Pamplona, Navarra 31008
SpainActive - Recruiting
Local Institution - 0062
Pamplona, Navarra 31008
SpainActive - Recruiting
Hospital Universitari Vall dHebron
Barcelona, 08035
SpainActive - Recruiting
Local Institution
Barcelona, 8035
SpainSite Not Available
Local Institution - 0009
Barcelona, 8026
SpainSite Not Available
Local Institution - 0046
Barcelona, 08035
SpainActive - Recruiting
Hospital Sant Juan de Deu Barcelona
Esplugues de Llobregat, 08950
SpainActive - Recruiting
Local Institution - 0069
Esplugues de Llobregat, 8950
SpainSite Not Available
Clinica Universidad de Navarra
Madrid, 28027
SpainActive - Recruiting
Hospital Infantil Universitario Nino Jesus
Madrid, 28009
SpainActive - Recruiting
Hospital Universitario 12 de Octubre
Madrid, 28041
SpainActive - Recruiting
Hospital Universitario La Paz
Madrid, 28046
SpainActive - Recruiting
Local Institution
Madrid, 28041
SpainSite Not Available
Local Institution - 0030
Madrid, 28009
SpainActive - Recruiting
Local Institution - 0044
Madrid, 28040
SpainSite Not Available
Local Institution - 0045
Madrid, 28046
SpainActive - Recruiting
Local Institution - 0055
Madrid, 28041
SpainActive - Recruiting
Local Institution - 0058
Madrid, 28027
SpainActive - Recruiting
Local Institution - 0011
Santander, 39008
SpainSite Not Available
Hospital Universitario Virgen del Rocio HUVR
Sevilla, 41013
SpainActive - Recruiting
Local Institution
Sevilla, 41013
SpainSite Not Available
Local Institution - 0023
Sevilla, 41013
SpainActive - Recruiting
Local Institution - 0038
Sevilla, 41009
SpainSite Not Available
Hospital Universitari i Politecnic La Fe
Valencia, 46026
SpainActive - Recruiting
Local Institution
Valencia,
SpainSite Not Available
Local Institution - 0049
Valencia, 46026
SpainActive - Recruiting
Cambridge University Hospitals NHS Foundation Trust
Cambridge, Cambridgeshire CB2 0QQ
United KingdomActive - Recruiting
Local Institution - 0075
Cambridge, Cambridgeshire CB2 0QQ
United KingdomSite Not Available
Alder Hey Children's NHS Foundation Trust
Liverpool, England L12 2AP
United KingdomActive - Recruiting
Local Institution - 0074
Liverpool, England L12 2AP
United KingdomSite Not Available
Local Institution - 0054
London, Londonderry NW1 2PG
United KingdomSite Not Available
UCLH
London, Londonderry NW1 2PG
United KingdomActive - Recruiting
Local Institution - 0003
Nottingham, Nottinghamshire NG5 1PB
United KingdomSite Not Available
Local Institution - 0050
Bristol, Somerset BS2 8BJ
United KingdomSite Not Available
Local Institution - 0053
Sutton, Surrey SM2 5PT
United KingdomSite Not Available
The Royal Marsden NHS Foundation Trust - Royal Marsden Hospital (RMH) - Sutton
Sutton, Surrey SM2 5PT
United KingdomSite Not Available
Local Institution - 0031
Birmingham, West Midlands B4 6NH
United KingdomSite Not Available
The Royal Marsden NHS Foundation Trust - Royal Marsden Hospital (RMH) - Sutton
London, SM2 5PT
United KingdomActive - Recruiting
Local Institution - 0068
Newcastle upon Tyne, NE1 4LP
United KingdomSite Not Available
Local Institution - 0077
Birmingham, Alabama 35233
United StatesSite Not Available
Phoenix Childrens Hospital PCH - Phoenix Childrens Medical Group - Hematology Oncology
Phoenix, Arizona 85016
United StatesActive - Recruiting
Lucile Packard Childrens Hospital - Stanford University
Palo Alto, California 94304
United StatesActive - Recruiting
Stanford University - Lucile Packard Childrens Hospital LPCH
Palo Alto, California 94304
United StatesActive - Recruiting
Yale University
New Haven, Connecticut 06510
United StatesActive - Recruiting
Local Institution - 0061
Wilmington, Delaware 19803
United StatesSite Not Available
Nemours Childrens Hospital
Wilmington, Delaware 19803
United StatesSite Not Available
Golisano Children',s Hospital of Southwest Florida
Fort Myers, Florida 33908
United StatesSite Not Available
Golisano Children's Hospital of Southwest Florida
Fort Myers, Florida 33908
United StatesActive - Recruiting
AdventHealth
Orlando, Florida 32804
United StatesSite Not Available
Local Institution
West Palm Beach, Florida 33407
United StatesSite Not Available
St. Mary's Medical Center
West Palm Beach, Florida 33407
United StatesSite Not Available
The Johns Hopkins Hospital JHH
Baltimore, Maryland 21287
United StatesActive - Recruiting
University of Minnesota Medical School - Masonic Childrens Hospital
Minneapolis, Minnesota 55454
United StatesActive - Recruiting
University Of Mississippi Medical Center
Jackson, Mississippi 39216
United StatesActive - Recruiting
University of Mississippi Medical Center
Jackson, Mississippi 39216
United StatesActive - Recruiting
Local Institution - 0012
Saint Louis, Missouri 63110
United StatesSite Not Available
Siteman Cancer Center - Washington University Medical Campus Location
Saint Louis, Missouri 63110
United StatesSite Not Available
Hackensack University Medical Center HUMC - The Joseph M. Sanzari Childrens Hospital - Children's Cancer Institute
Hackensack, New Jersey 07601
United StatesActive - Recruiting
Local Institution - 0016
Bronx, New York 10467
United StatesSite Not Available
Montefiore Medical Center
Bronx, New York 10467
United StatesSite Not Available
Columbia University Medical Center
New York, New York 10032
United StatesActive - Recruiting
New York Medical College
Valhalla, New York 10595
United StatesActive - Recruiting
Local Institution - 0019
Hershey, Pennsylvania 17033
United StatesSite Not Available
Penn State Health Milton S. Hershey Medical Center - Penn State Children's Hospital
Hershey, Pennsylvania 17033
United StatesSite Not Available
Local Institution - 0014
Nashville, Tennessee 37232
United StatesSite Not Available
Vanderbilt-Ingram Cancer Center
Nashville, Tennessee 37232
United StatesActive - Recruiting
Dell Children's Medical Center of Central Texas (DCMC) - Strictly Pediatrics Subspecialty Center
Austin, Texas 78723
United StatesSite Not Available
CHRISTUS Childrens
San Antonio, Texas 78207
United StatesActive - Recruiting
CHRISTUS Santa Rosa Childrens Hospital CSRCH - The Howard A. Britton M.D. Childrens Cancer and Blood Disorders Center
San Antonio, Texas 78207
United StatesSite Not Available
Local Institution - 0076
Norfolk, Virginia 23507
United StatesSite Not Available
UW Health - American Family Children's Hospital Pediatric Bone Marrow Transplant Clinic
Madison, Wisconsin 53792
United StatesSite Not Available
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