Diaphragm Atrophy and Dysfunction in Mechanical Ventilation

Last updated: October 25, 2022
Sponsor: RWTH Aachen University
Overall Status: Active - Recruiting

Phase

N/A

Condition

Lung Injury

Respiratory Failure

Treatment

N/A

Clinical Study ID

NCT05211661
CTCA 21-279
  • Ages 18-75
  • All Genders

Study Summary

The gold standard of twitch transdiaphragmatic pressure recordings would ultimately clear the fog around the rate of development of Ventilator induced Diaphragm Dysfunction (VIDD) in mechanically ventilated patients over time.

Through measurements made even after mechanical ventilation (MV) it could be clarified to what extent patients recover from VIDD.

Paired with cortical stimulation and electromyographic recordings of diaphragm muscle potentials, it could be explored to what extent decreased diaphragm excitability due to long term MV contributes to VIDD on the level of motor cortex.

Against that background the present project aims at determining the rate of decline in diaphragm function, strength and control in patients undergoing MV (including measurements after extubation).

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Initiation of invasive mechanical ventilation in the Intensive Care Unit within 48hours.
  • Expected duration of invasive mechanical ventilation of at least 5 days.

Exclusion

Exclusion Criteria:

  • Body-mass-index (BMI) >40
  • Expected absence of active participation of the patient in study-related measurementsafter extubation
  • Alcohol or drug abuse
  • Non MRI compatible implant in the body
  • Slipped disc
  • Epilepsy
  • Patients in an interdependence or with an employment contract with the principalinvestigator, Co-PI or his deputy.

Study Design

Total Participants: 15
Study Start date:
October 10, 2022
Estimated Completion Date:
December 01, 2023

Study Description

Evidence both from animal and human studies support the development of ventilator induced diaphragm dysfunction (VIDD) from as early as 24 hours of mechanical ventilation (MV) in the intensive care unit (ICU).

However, while the concept of VIDD seems to be proven now, several questions remain unanswered regarding its actual rate of development and (potentially) recovery after MV.

The gold standard of twitch transdiaphragmatic pressure recordings would ultimately clear the fog around the rate of development of VIDD over time.

Through measurements made even after MV it could be clarified to what extent patients recover from VIDD.

Paired with cortical stimulation and electromyographic recordings of diaphragm muscle potentials, it could be explored to what extent decreased diaphragm excitability due to long term MV contributes to VIDD on the level of motor cortex.

Against that background the present project aims at determining the rate of decline in diaphragm function, strength and control in patients undergoing MV (including measurements after extubation).

Connect with a study center

  • RWTH Aachen University

    Aachen, 52074
    Germany

    Active - Recruiting

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