The Effect of Dietary Intervention on Endothelial Glycocalyx in Psoriasis

Last updated: May 14, 2023
Sponsor: University of Athens
Overall Status: Active - Recruiting

Phase

N/A

Condition

Warts

Rash

Rosacea

Treatment

Placebo

Food supplement Endocalyx

Clinical Study ID

NCT05184699
672/2-12-2021
  • Ages 18-75
  • All Genders

Study Summary

The food supplement Endocalyx is considered to support the endothelial glycocalyx integrity by supplying sulfated polysaccharides, anti-oxidant enzymes and additional substrates for glycocalyx synthesis. The investigators will study the effect of Endocalyx on endothelial, vascular and left ventricular myocardial function in patients with psoriatic disease.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Caucasian patients with psoriatic disease (plaque-type psoriasis or psoriaticarthritis)
  • Body mass index ≥18.5 Kg/m2
  • If female, patients must be non-pregnant and non-breastfeeding

Exclusion

Exclusion Criteria:

  • History of acute coronary syndrome. Coronary artery disease will be excluded by aclinical history, examination and electrocardiogram.
  • Moderate or severe valve disease
  • Primary cardiomyopathies
  • Chronic obstructive pulmonary disease
  • Asthma
  • Chronic kidney disease
  • Liver failure
  • Malignancies

Study Design

Total Participants: 60
Treatment Group(s): 2
Primary Treatment: Placebo
Phase:
Study Start date:
November 01, 2022
Estimated Completion Date:
January 30, 2024

Study Description

Sixty patients with psoriatic disease, who are referred to the outpatient psoriasis clinic of the Attikon University Hospital, will be randomized to receive food supplement Endocalyx (4 capsules per day) (n=30) or placebo (n=30) for 4 consecutive months.

Connect with a study center

  • Attikon University Hospital

    Athens, Attiki 12462
    Greece

    Active - Recruiting

Not the study for you?

Let us help you find the best match. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.